17046-84-3

Usage

Uses

Used in Pharmaceutical Synthesis:
1,4-Ditosylpiperazine is used as a versatile intermediate for the synthesis of pharmaceuticals, leveraging its strong nucleophilic reactivity to facilitate the formation of essential carbon-carbon and carbon-nitrogen bonds in the creation of complex molecules with specific biological activities.
Used in Organic Chemistry:
In the field of organic chemistry, 1,4-Ditosylpiperazine is employed as a reagent in the preparation of various heterocyclic compounds, contributing to the development of novel chemical entities with potential applications in different industries.
Used in Drug Development:
1,4-Ditosylpiperazine has been investigated for its potential as a precursor in the development of new drug candidates, indicating its utility in the advancement of treatments for a range of diseases and medical conditions.

Upstream product

• 4403-78-5 ditosylethylenediamine 
• 19263-21-9 2-bromoethyl p-toluenesulfonate 
• 107-06-2 1,2-dichloro-ethane 
• 1243273-34-8 N,N'-di(p-toluenesulfonyl)-N-[2-[(o-nitrophenyl)(p-toluenesulfonyl)amino]ethyl]-1,2-ethylenediamine 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 18522-92-4 sodium p-toluenesulfonamide 
• 6315-52-2 1,2-bis-tosyloxyethane 
• 70-55-3 toluene-4-sulfonamide 
• 99142-37-7 N-<2-p-Toluolsulfonyloxy-ethyl>-N,N'-di-p-toluolsulfonyl-ethylendiamin 
• 1074-82-4 potassium phtalimide 
• 23545-41-7 N-(2-bromo-ethyl)-ethylenediamine; dihydrobromide 
• 98-59-9 p-toluenesulfonyl chloride 
• 106-93-4 ethylene dibromide 
• 80-41-1 2-chloroethyl tosylate 

Downstream Products

• 110-85-0 piperazine 

Relevant academic research and scientific papers

Aryl(sulfonyl)amino group: A convenient and stable yet activated modification of amino group for its intramolecular displacement

Aryl(sulfonyl)amino groups, readily derived from sulfonyl- or arylamines by standard methods as well as the recently introduced methods of sulfonylation and arylation, proved to be good leaving groups in intramolecular substitution reactions by various nitrogen, oxygen, and carbon nucleophiles.

Alkali metals in silica gel (M-SG): A new reagent for desulfonation of amines

(Chemical Equation Presented) A novel method for the desulfonation of secondary amines is described. Alkali metals absorbed into nanostructured silica (M-SG) were found to be useful solid-state reagents for the desuffonation of a range of N,N-disubstituted sulfonamides. M-SG reagents are room-temperature- stable free-flowing powders that retain the chemical reactivity of the parent metal, decreasing the danger and associated cost of using reactive metals.

Microwave-assisted synthesis of 1,4,7,10-tetraazacyclododecane

Tosylated cyclen is synthesized by the condensation of tritosylated diethanolamine and tosylamide monosodium salt under microwave irradiation, which, on detosylation with HBr, gives cyclen dihydrobromide. X-ray crystal structure of cyclen dihydrobromide i

Organic Synthesis Using PTC: Part 8 - Synthesis of Macrocylic Systems Containing Nitrogen and/or Oxygen as Heteroatom(s)

Reactions of p-toluene/benzenesulphonamides with p-toluenesulphonate ester of diols under liquid-liquid and solid-liquid phase transfer (PT) conditions give cyclic N-p-toluenesulphonyl or N-benzenesulphonyl derivatives with 1:1 and/or 2:2 stoichiometries.Thus, the cyclic system containing N and/or O as heteroatom(s) have been procured usimg this procedure.

N-(ω-TOSYLOXYALKYL)PHTHALIMIDES AS REACTIVE GENERAL SYNTHONS FOR INTRODUCING ALKYLAMINO GROUPS AND THEIR APPLICATION FOR THE "SELF-PROLIFERATIVE" SYNTHESIS OF OPEN-CHAIN POLYAMINES

New synthetic routes to N-(ω-tosyloxyalkyl)phthalimides (2) were developed and the synthetic utility of 2 as alkylating reagents was exemplified in the open-chain polyamine synthesis involving the "self-proliferative" process.

Bifunctionalization of α,ω-Sulphonamides via Kinetically Controlled Reaction of α,ω-Bis(N-nitrososulphonamides)

α,ω-Bis(N-nitrososulphonamides) in hot benzene were converted into α,ω-disulphonates and bifunctional α-sulphonate-ω-sulphonamides, in good yields, by intramolecular N-nitrososulphonamide-sulphonate rearrangement.

N,N-Disulfonylpiperazines

This invention is directed to a novel series of piperazine derivatives having the general structure STR1 wherein R and R' may be: STR2