170465-55-1Relevant academic research and scientific papers
The asymmetric synthesis of γ-substituted glutamic acid derivatives via a glutamic acid γ-enolate synthon
Del Bosco, Marco,Johnstone, Andrew N.C.,Bazza, Giorgia,Lopatriello, Stefania,North, Michael
, p. 8545 - 8554 (1995)
Treatment of α-t-butyl γ-methyl N-Z glutamate with lithium hexamethyldisilazide gives the γ-enolate regioselectively. Reaction of this enolate with electrophiles gives γ-substituted glutamic acid derivatives including the conformationally constrained glut
Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration
Kondo, Takashi,Nekado, Takahiro,Sugimoto, Isamu,Ochi, Kenya,Takai, Shigeyuki,Kinoshita, Atsushi,Tajima, Yohei,Yamamoto, Susumu,Kawabata, Kazuhito,Nakai, Hisao,Toda, Masaaki
, p. 2631 - 2650 (2008/02/05)
A series of 5β-methylprolyl-2-cyanopyrrolidine analogs were synthesized and evaluated as DPP-IV inhibitors, and the duration of their ex vivo activity was assessed. Comparison of their potency and duration of action was done among three different species.
