The asymmetric synthesis of γ-substituted glutamic acid derivatives via a glutamic acid γ-enolate synthon

Article abstract of DOI:10.1016/0040-4020(95)00455-H

Treatment of α-t-butyl γ-methyl N-Z glutamate with lithium hexamethyldisilazide gives the γ-enolate regioselectively. Reaction of this enolate with electrophiles gives γ-substituted glutamic acid derivatives including the conformationally constrained glut