170491-61-9

Basic information

• Product Name: 1-Boc-2-(2-Oxoethyl)Piperidine
• Synonyms: 1-Boc-2-(2-Oxoethyl)Piperidine;1-Piperidinecarboxylic acid, 2-(2-oxoethyl)-, 1,1-diMethylethyl ester;tert-Butyl 2-(2-oxoethyl)piperidine-1-carboxylate;2-(2-oxoethyl)-1-Piperidine carbocylic acid 1,1-dimethylethyl ester;tert-Butyl 2-(2-oxoethyl)
• CAS NO: 170491-61-9
• Molecular Formula: C₁₂H₂₁NO₃
• Molecular Weight: 227.30004
• Mol File: 170491-61-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Boc-2-(2-Oxoethyl)Piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-2-(2-Oxoethyl)Piperidine(170491-61-9)
• EPA Substance Registry System: 1-Boc-2-(2-Oxoethyl)Piperidine(170491-61-9)

Safety Data

• Hazardous Substances Data: 170491-61-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Boc-2-(2-Oxoethyl)Piperidine is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows for the creation of a wide range of molecules with potential therapeutic applications.
Used in Medicinal Chemistry:
1-Boc-2-(2-Oxoethyl)Piperidine is used as a protecting group for amines in organic synthesis, which is crucial for the development of new drugs and the modification of existing ones. Its ability to protect amines during chemical reactions ensures that the desired products are formed without unwanted side reactions.
Used in Drug Discovery:
1-Boc-2-(2-Oxoethyl)Piperidine is used in the field of drug discovery to facilitate the synthesis of new compounds with potential therapeutic properties. Its versatility and stability make it an ideal candidate for use in the development of novel drugs and drug candidates.

Upstream product

• 109-92-2 ethyl vinyl ether 
• 195964-51-3 tert-butyl 2-methoxypiperidine-1-carboxylate 
• 118667-62-2 tert-butyl 2-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 
• 2739-99-3 2-ethoxycarbonylmethylpiperidine 
• 118811-03-3 tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate 

Downstream Products

• 946484-92-0 2-[2-hydroxy-3-(methoxycarbonyl)-3-(phenylseleno)pentyl]piperidine-1-carboxylic acid tert-butyl ester 
• 946484-96-4 2-[2-hydroxy-3-(methoxycarbonyl)-4-methyl-3-(phenylseleno)pentyl]piperidine-1-carboxylic acid tert-butyl ester 
• 946485-01-4 2-[3-cyano-2-hydroxy-3-(phenylseleno)butyl]piperidine-1-carboxylic acid tert-butyl ester 
• 946485-06-9 2-[3-(benzenesulfonyl)-2-hydroxy-3-(phenylseleno)butyl]piperidine-1-carboxylic acid tert-butyl ester 
• 170491-66-4 N-t-butyloxycarbonyl-(2-cinnamyl)piperidine 
• 170492-12-3 C₁₉H₂₇NO₂ 
• 1174068-39-3 C₂₀H₃₁NO₅S 
• 1174068-40-6 4-[1-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-piperidin-2-yl]-butyric acid 
• 182343-68-6 (2-Iodo-phenyl)-[2-(3-trimethylsilanyl-prop-2-ynyl)-piperidin-1-yl]-methanone 
• 95687-85-7 (8-azabicyclo[3.2.1]octan-8-yl)(phenyl)methanone 
• 460997-29-9 2-[(1-benzyl-6-oxo-1,4,5,6-tetrahydro-pyridin-3-yl)-2-oxo-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 460997-30-2 2-[2-(1-benzyl-6-oxo-1,4,5,6-tetrahydro-pyridin-3-yl)-2-hydroxy-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis of Azocanes from Piperidines via an Azetidinium Intermediate

α-Trifluoromethyl azocanes are accessible from 2-(trifluoropropan-2-ol) piperidines by metal-free ring-expansion involving a bicyclic azetidinium intermediate. The opening of the azetidinium intermediate was achieved by various nucleophiles (amines, alcoholates, carboxylates, phosphonates, halides and pseudo-halides) with an excellent regio- diastereo- and enantioselectivity and in good yields. The relative configuration of the piperidines and azocanes were assigned and the deprotected azocanes offer opportunities for further derivatization.

Catalytic Oxygenative Allylic Transposition of Alkenes into Enones with an Azaadamantane-Type Oxoammonium Salt Catalyst

The first catalytic oxygenative allylic transposition of unactivated alkenes into enones has been developed using an oxoammonium salt as the catalyst. This reaction converts various tri- and trans-disubstituted alkenes into their corresponding enones with transposition of their double bonds at ambient temperature in good yields. The use of a less-hindered azaadamantane-type oxoammonium salt as the catalyst and a combination of two distinct stoichiometric oxidants, namely, iodobenzene diacetate and magnesium monoperoxyphthalate hexahydrate (MMPP?6 H2O) are essential to facilitate the enone formation efficiently.

USE OF AMINOINDANE COMPOUNDS IN TREATING OVERACTIVE BLADDER AND INTERSTITIAL CYSTITIS

The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the compounds to a patient.

Aminoindane Compounds and Use Thereof in Treating Pain

The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) or (II) and a TRPV 1 receptor activator. In one embodiment, the TRPV 1 receptor activator is lidocaine.

Regioselective synthesis of azetidines or pyrrolidines by selenium-induced cyclization of secondary homoallylic amines

Azetidines or pyrrolidines can be regioselectively obtained by selenocyclization of homoallylic amines, according to the double bond substitution.

Substituted Spiroamine Compounds

Substituted spiroamine compounds corresponding to the formula (I) In which m, n, o, p, Q, r, s, t, R1, R2, R3, R4a, R4b, R5a, R5b, R6a, R6b, R7, R8, R9, R10 and R11 have defined meanings; a process for the preparation of such compounds, pharmaceutical compositions containing such compounds and the use of substituted spiroamines for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin 1 receptor.

Stereocontrol in N-directed hydroboration: Synthesis of amino alcohols related to the piperidine alkaloids

Treatment of 2-(2'-alkenyl)-piperidine boranes with iodine or triflic acid induces internal hydroboration with high regiocontrol, even with a terminal alkene (R H). Good stereocontrol is possible for the N-benzyl substrates. Comparisons with acyclic model

Microwave-assisted synthesis of novel (5-nitropyridin-2-yl)alkyl and (5-nitropyridin-3-yl)alkyl carbamates

A straightforward approach to novel (5-nitropyridin-2-yl)alkyl and (5-nitropyridin-3-yl)alkyl carbamate building blocks is presented in this study. Their construction is achieved by condensation of N-carbamate a- and β-amino carbonyl derivatives with l-methyl-3,5-dinitro-2-pyridone 1 under microwave irradiation. Judiciously chosen modifications in the nature of the parent carbonyl starting material has influenced the regiochemical outcome of the reaction and allowed an efficient access to novel nitrogen-containing scaffolds. Compounds sharing morphological similarities have been gathered in three libraries differing from each other in a single structural parameter.

SUBSTITUTED SULFONAMIDE DERIVATIVES

The invention relates to substituted sulfonamide derivatives of the general formula (I'); processes for their preparation, medicaments containing these compounds, and the use of substituted sulfonamide derivatives for the preparation of medicaments

Total syntheses of the tylophora alkaloids cryptopleurine, (-)-antofine, (-)-tylophorine, and (-)-ficuseptine C

A concise, efficient and modular approach to the tylophora alkaloids is described, a family of potent cytotoxic agents that are equally effective against drug sensitive and multidrug resistant cancer cell lines. The advantages of the chosen route are illustrated by the total syntheses of the phenanthroquinolizidine cryptopleurine (1) and the phenanthroindolizidines (-)-antofine (2), (-)-tylophorine (3), and their only recently isolated congener (-)-ficuseptine C (4). The key steps consist in a Suzuki cross-coupling between a (commercial) boronic acid and a simple aryl-l,2-dihalide followed by elaboration of the resulting products into the corresponding 2-alkynyl-biphenyl derivatives 27, 33, 41 and 46. The latter undergo PtCl2-catalyzed cycloisomerizations with formation of the functionalized phenanthrenes 28, 34, 42 and 47, which were transformed into the targeted alkaloids by a deprotection/Pictet-Spengler annulation tandem. Due to the flexibility and robust character of this approach, it might enable a systematic exploration of the pharmacological profile of this promising class of bioactive natural products.