95687-85-7

Basic information

• Product Name: 8-Azabicyclo[3.2.1]octane, 8-benzoyl-
• CAS NO: 95687-85-7
• Molecular Formula: C14H17NO
• Molecular Weight: 215.295
• Mol File: 95687-85-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 8-Azabicyclo[3.2.1]octane, 8-benzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Azabicyclo[3.2.1]octane, 8-benzoyl-(95687-85-7)
• EPA Substance Registry System: 8-Azabicyclo[3.2.1]octane, 8-benzoyl-(95687-85-7)

Safety Data

• Hazardous Substances Data: 95687-85-7(Hazardous Substances Data)

Upstream product

• 529-17-9 tropane 
• 65-85-0 benzoic acid 
• 95687-93-7 trans-1-(benzoylamino)-4-chlorocycloheptane 
• 876938-53-3 Cyclohepta-1,3-diene 
• 495-18-1 Benzohydroxamic acid 
• 98-88-4 benzoyl chloride 
• 95205-45-1 5-{(3aR,5S,6S,6aR)-5-(tert-Butyl-dimethyl-silanyloxy)-6-[(E)-(R)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl}-pentanoic acid 
• 95687-90-4 N-((1S,4R)-4-Hydroxy-cyclohept-2-enyl)-benzamide 
• 95687-91-5 N-((1S,4R)-4-Hydroxy-cycloheptyl)-benzamide 
• 182343-67-5 tert-butyl 2-(3-trimethylsilyl-2-propynyl)piperidine-1-carboxylate 
• 182343-66-4 2-(3,3-dibromo-2-propenyl)-1-piperidinecarboxylic acid tert-butyl ester 
• 170491-61-9 2-(2-oxoethyl)-1-piperidinecarboxylic acid tert-butyl ester 
• 118811-03-3 tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate 
• 609-67-6 2-Iodobenzoyl chloride 

Downstream Products

• 18717-73-2 (1R,3r,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-ol 

Relevant articles and documents

Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C-H Functionalization

Reliable regio- and stereochemical techniques applicable to nonactivated aliphatic systems remain largely elusive due to the challenges of discriminating between multiple, relatively strong sp3 C-H bonds whose chemical behavior often differ onl

Synthesis of bridged azabicyclic compounds using raducal translocation reactions of 1-(o-bromobenzoyl)-2-(prop-2-enyl)pyrrolidines

A new synthesis of the 7-azabicycloheptane and 8-azabicyclooctane systems is described in which α-acylamino radicals generated from 1-(o-bromobenzoyl-2-(prop-2-enyl)pyrrolidines by a Bu3SnH-mediated radical translocation reaction are cyclised.Treatment of methyl 1-(o-bromobenzoyl)-2-(prop-2-enyl)pyrrolidine-2-carboxylate 3a with Bu3SnH in the presence of a catalytic amount of azoisobutyronitrile in boiling toluene gave the 7-azabicycloheptane 4a (a 5-exo cyclisation product) and the 8-azabicyclooctane 5a (a 6-endo product) (30percent), together with the reduction product 6a (12percent).The geriochemistry (5-exo/6-endo) of this cyclisation could be controlled by the introduction of a substituent on the prop-2-enyl group.The substituent(s) at the 2- and/or 4-position(s) of the pyrrolidine ring were found to play an important role in this cyclisation.

A new synthetic route to tropane alkaloids based on [4 + 2] nitroso cycloaddition to 1,3-cycloheptadienes

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