1705-09-5

Usage

Uses

Used in Pharmaceutical Industry:
2-MERCAPTO-3-METHYL-3H-QUINAZOLIN-4-ONE is used as an anti-inflammatory and analgesic agent for its ability to reduce pain and inflammation. It is particularly effective in treating conditions such as arthritis and menstrual cramps, where prostaglandin production contributes to discomfort and swelling.
Used in Pain Management:
2-MERCAPTO-3-METHYL-3H-QUINAZOLIN-4-ONE is used as a pain reliever for various types of pain, including chronic and acute conditions. Its mechanism of action in reducing prostaglandin synthesis helps alleviate pain by decreasing inflammation and nerve sensitivity.
Used in Cancer Research:
2-MERCAPTO-3-METHYL-3H-QUINAZOLIN-4-ONE is used as a subject of research for its potential anti-cancer effects. Studies are exploring its ability to work synergistically with other chemotherapeutic agents, which may enhance the effectiveness of cancer treatments and potentially lead to new therapeutic approaches.

InChI:InChI=1/C9H8N2OS/c1-11-8(12)6-4-2-3-5-7(6)10-9(11)13/h2-5H,1H3,(H,10,13)

Upstream product

• 89861-48-3 3-methyl-1-palmitoyloxy-2-thioxo-1,2-dihydroquinazoline-4-(3H)-one 
• 82018-09-5 2-mercapto-4(3H)-quinazolinone sodium salt 
• 80-48-8 methyl p-toluene sulfonate 
• 106130-36-3 2-tert-Butyldisulfanyl-3-methyl-3H-quinazolin-4-one 

Downstream Products

• 607-19-2 3-methyl-2,4(1H,3H)-quinazolinedione 
• 61507-80-0 2-hydrazino-3-methyl-4a,8a-dihydro-3H-quinazolin-4-one 
• 6437-06-5 2-(methylsulfanyl)-3-methyl-quinazolin-4(3H)-one 
• 94392-54-8 anhydro-1-hydroxy-4-methyl-5-oxo-2-phenyl-4H-thiazolo<3,2-a>quinazolinum hydroxide 

Relevant academic research and scientific papers

The Invention of New Radical Chain Reactions. Part 9. Further Radical Chemistry of Thiohydroxamic Esters; Formation of Carbon-Carbon Bonds

Carbon radicals derived from the esters of several types of thiohydroxamic acids have been trapped in a number of different ways.Particular attention has been paid to carbon-carbon bond formation by addition to suitably activated ethylenic linkages.Carboxylic acids can be conveniently converted into homo- and bishomo-acids by free radical chemistry based on thiohydroxamic esters.In a coda the tautomerism of the thiohydroxamic acids have been examined by physical methods.It is confirmed that the esters used are derivatives of the thione tautomer.

RADICAL CHEMISTRY OF THIOHYDROXAMIC ACID ESTERS

Thiohydroxamic esters in general decompose smoothly by a radical chain reaction to give carbon radicals which can be quenched in a synthetically useful manner.

SYNTHESIS AND ALKYLATION OF 2-MERCAPTO-4-QUINAZOLONE AND THE FUNGICIDAL ACTIVITIES OF THE COMPOUNDS OBTAINED

A convenient method of obtaining 2-mercapto-4-quinazolone has been developed and the alkylation of its ambidentate anions has been studied.It has been found that they exhibit a dual reactivity in alkylation reactions.It has been shown that alkylated 2-mercapto-4-quinazolones possess a moderate fungicidal activity.