61507-80-0

Basic information

• Product Name: 2-HYDRAZINO-3-METHYLQUINAZOLIN-4(3H)-ONE
• Synonyms: 2-hydrazinyl-3-methylquinazolin-4-one
• CAS NO: 61507-80-0
• Molecular Formula: C₉H₁₀N₄O
• Molecular Weight: 190.21
• Mol File: 61507-80-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 365.5 °C at 760 mmHg
• Flash Point: 174.9 °C
• Appearance: /
• Density: 1.42 g/cm³
• Vapor Pressure: 1.56E-05mmHg at 25°C
• Refractive Index: 1.697
• CAS DataBase Reference: 2-HYDRAZINO-3-METHYLQUINAZOLIN-4(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDRAZINO-3-METHYLQUINAZOLIN-4(3H)-ONE(61507-80-0)
• EPA Substance Registry System: 2-HYDRAZINO-3-METHYLQUINAZOLIN-4(3H)-ONE(61507-80-0)

Safety Data

• Hazardous Substances Data: 61507-80-0(Hazardous Substances Data)

Usage

General Description

2-HYDRAZINO-3-METHYLQUINAZOLIN-4(3H)-ONE is a chemical compound with the molecular formula C9H8N4O. It is a quinazolinone derivative with a hydrazine group attached to the second carbon atom and a methyl group attached to the third carbon atom. 2-HYDRAZINO-3-METHYLQUINAZOLIN-4(3H)-ONE is a potential therapeutic agent with various biological activities, including antitumor and antiviral properties. It has been studied for its potential as an anticancer agent and has shown promising results in inhibiting the growth of cancer cells. Additionally, 2-HYDRAZINO-3-METHYLQUINAZOLIN-4(3H)-ONE has shown antiviral activity against certain viruses, making it a potential candidate for the development of antiviral medications. Overall, this chemical compound has potential applications in the fields of medicine and pharmaceuticals.

InChI:InChI=1/C9H10N4O/c1-13-8(14)6-4-2-3-5-7(6)11-9(13)12-10/h2-5H,10H2,1H3,(H,11,12)

Upstream product

• 1705-09-5 2-mercapto-3-methyl-3,4-dihydroquinazolin-4-one 
• 16024-82-1 methyl 2-isothiocyanatobenzoate 
• 134-20-3 2-carbomethoxyaniline 
• 6437-06-5 2-(methylsulfanyl)-3-methyl-quinazolin-4(3H)-one 
• 1705-09-5 3-methyl-4-oxoquinazoline-2-thione 
• 118-92-3 anthranilic acid 

Downstream Products

• 123566-11-0 3-Methyl-2-{N'-[1-phenyl-meth-(Z)-ylidene]-hydrazino}-3H-quinazolin-4-one 
• 1134193-72-8 2-[2-[1'-(4-chlorophenyl)-3'-(2-thienyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 1134193-74-0 2-[2-[1'-(4-methylphenyl)-3'-(2-furyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 1134193-76-2 2-[2-[1'-(4-methoxyphenyl)-3'-(2-furyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 1134193-71-7 2-[2-[1'-(4-methylphenyl)-3'-(2-thienyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 1134193-75-1 2-[2-[1'-(4-chlorophenyl)-3'-(2-furyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 1134193-73-9 2-[2-[1'-(4-methylphenyl)-3'-(2-thienyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 123566-07-4 3-[(E)-2-(4-Methoxy-phenyl)-vinyl]-10-methyl-10H-1,2,4a,10-tetraaza-phenanthrene-4,9-dione 

Relevant articles and documents

Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents

A series of 1-phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5-ones designed as conformationally restricted CA-4 analogues, were tested for their tubulin polymerization and growth inhibitory activities. The 3-hydroxy-4-methoxy derivatives 11d and 12d are potent inhibitors of tubulin assembly but only the N-methylated amid counterpart 12d possesses potent anticancer activity in a large panel of cancer cell lines. Upon treatment with compound 12d, remarkable cell shape changes as cell migration and tube formation were elicited in HUVECs, consistent with vasculature damaging activity.

New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: Synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity

A new series of pyrazoline derivatives were prepared starting from a quinazolinone ring and evaluated for antidepressant, anxiogenic and MAO-A and -B inhibitory activities by in vivo and in vitro tests, respectively. Most of the synthesized compounds show

Regioselectivity of electrophilic attack on 4-methyl-1-thioxo-1,2,4,5- tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one. Part 1: Reactions at the sulfur atom

The regioselectivity of the model compound 4-methyl-1-thioxo-1,2,4,5- tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one (3) towards different electrophiles was studied. Compound 3 reacts with alkyl and aryl halides to give the corresponding S-substituted derivatives. The reaction of the model thioamide with acyl halides proceeds by the formation of kinetically controlled S-acyl derivatives followed by a transacylation reaction to give the N 2-acyl derivatives as thermodynamically controlled products. Theoretical DFT computational studies supported the explanation of these results. The synthesized compounds were characterized by FTIR, 1H-NMR, 13C-NMR, and mass spectroscopy.