61507-80-0

Usage

Uses

Used in Pharmaceutical Industry:
2-HYDRAZINO-3-METHYLQUINAZOLIN-4(3H)-ONE is used as a potential therapeutic agent for its antitumor properties, making it a candidate for the development of anticancer medications. Its ability to inhibit the growth of cancer cells has shown promise in early studies, suggesting its potential use in combating cancer.
Used in Antiviral Medications:
In the field of virology, 2-HYDRAZINO-3-METHYLQUINAZOLIN-4(3H)-ONE is used as a potential antiviral agent. Its demonstrated antiviral activity against certain viruses indicates its possible application in creating medications to treat viral infections.

InChI:InChI=1/C9H10N4O/c1-13-8(14)6-4-2-3-5-7(6)11-9(13)12-10/h2-5H,10H2,1H3,(H,11,12)

Upstream product

• 118-92-3 anthranilic acid 
• 6437-06-5 2-(methylsulfanyl)-3-methyl-quinazolin-4(3H)-one 
• 16024-82-1 methyl 2-isothiocyanatobenzoate 
• 134-20-3 2-carbomethoxyaniline 
• 1705-09-5 3-methyl-4-oxoquinazoline-2-thione 
• 1705-09-5 2-mercapto-3-methyl-3,4-dihydroquinazolin-4-one 

Downstream Products

• 123566-11-0 3-Methyl-2-{N'-[1-phenyl-meth-(Z)-ylidene]-hydrazino}-3H-quinazolin-4-one 
• 127570-96-1 1-Mercapto-4-methyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one 
• 127570-96-1 4-methyl-1-thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one 
• 123566-06-3 10-Methyl-3-phenyl-10H-1,2,4a,10-tetraaza-phenanthrene-4,9-dione 
• 123566-08-5 3-[(E)-2-(4-Chloro-phenyl)-vinyl]-10-methyl-10H-1,2,4a,10-tetraaza-phenanthrene-4,9-dione 
• 123566-07-4 3-[(E)-2-(4-Methoxy-phenyl)-vinyl]-10-methyl-10H-1,2,4a,10-tetraaza-phenanthrene-4,9-dione 
• 1134193-72-8 2-[2-[1'-(4-chlorophenyl)-3'-(2-thienyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 1134193-74-0 2-[2-[1'-(4-methylphenyl)-3'-(2-furyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 1134193-76-2 2-[2-[1'-(4-methoxyphenyl)-3'-(2-furyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 1134193-71-7 2-[2-[1'-(4-methylphenyl)-3'-(2-thienyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 1134193-75-1 2-[2-[1'-(4-chlorophenyl)-3'-(2-furyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 
• 1134193-73-9 2-[2-[1'-(4-methylphenyl)-3'-(2-thienyl)-2'-propenylidene]hydrazino]-3-methyl-4(3H)-quinazolinone 

Relevant academic research and scientific papers

Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents

A series of 1-phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5-ones designed as conformationally restricted CA-4 analogues, were tested for their tubulin polymerization and growth inhibitory activities. The 3-hydroxy-4-methoxy derivatives 11d and 12d are potent inhibitors of tubulin assembly but only the N-methylated amid counterpart 12d possesses potent anticancer activity in a large panel of cancer cell lines. Upon treatment with compound 12d, remarkable cell shape changes as cell migration and tube formation were elicited in HUVECs, consistent with vasculature damaging activity.

Synthesis of novel quinazoline-4-one derivatives and their acyclonucleoside analogs

A number of quinazolin-4-one derivatives were synthesized. Reaction of the 2-hydrazonoquinazoline-4-one derivatives with aldoses afforded the corresponding sugar hydrazones which on treatment with ferric chloride to afford the corresponding acyclic nucleoside analogues.

New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: Synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity

A new series of pyrazoline derivatives were prepared starting from a quinazolinone ring and evaluated for antidepressant, anxiogenic and MAO-A and -B inhibitory activities by in vivo and in vitro tests, respectively. Most of the synthesized compounds show

Synthesis of new 4(3H)-quinazolinone derivatives using 5(4H)-oxazolones

New derivatives of 5(4H)-quinazolinone containing 2-imidazolin-5-one rings have been prepared from 5(4H)-oxazolone derivatives.

Regioselectivity of electrophilic attack on 4-methyl-1-thioxo-1,2,4,5- tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one. Part 1: Reactions at the sulfur atom

The regioselectivity of the model compound 4-methyl-1-thioxo-1,2,4,5- tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one (3) towards different electrophiles was studied. Compound 3 reacts with alkyl and aryl halides to give the corresponding S-substituted derivatives. The reaction of the model thioamide with acyl halides proceeds by the formation of kinetically controlled S-acyl derivatives followed by a transacylation reaction to give the N 2-acyl derivatives as thermodynamically controlled products. Theoretical DFT computational studies supported the explanation of these results. The synthesized compounds were characterized by FTIR, 1H-NMR, 13C-NMR, and mass spectroscopy.

Pesticidal dihydrotetrazolo [1,5-a] quinazoline compound and processes and compositions for using the same

A dihydrotetrazolo[1,5-a]quinazoline compound which in free base form has the formula: STR1 wherein R3 is hydrogen, hydroxy or dialkylamino of from 1 to 4 carbon atoms; R2 is dialkylamino when R3 is dialkylamino and R2 is hydrogen when R3 is hydrogen or hydroxy; and R is a lower alkyl of from 1 to 4 carbon atoms. Pesticidal compositions containing such compound and priocesses for using the same to combat pests, especially fungi, are also disclosed.