170508-52-8Relevant academic research and scientific papers
Synthesis of Oxochlorins from the Red Blood Pigment Heme and Their Transformation into Potentially Biologically Active Chlorin Derivatives
Bats, Jan W.,Haake, Gerold,Meier, Axel,Montforts, Franz-Peter,Scheurich, Gerhard
, p. 1617 - 1632 (2007/10/02)
The hydrochlorin rac-3 was prepared from the readily accessible chlorins rac-5a, b.The alcohol function of rac-3 could be used to attach an estrogen residue 28 and the hydroquinone 19 to yield the chlorin estrogen ethers 32a, b and the chlorin hydroquinone ether rac-30 respectively.The prepared chlorin estrogen derivatives might be useful as sensitizers and fluorescence markers for photodynamic therapy and other diagnostic/therapeutic applications.The chlorin hydroquinone ether is of interest as a potential artificial photosynthesis system, which contains a "natural" chlorin as a structural subunit in contrast to previously synthesized model systems based on porphyrins. - Keywords: Porphyrins / Chlorins / Estradiols / Quinones / Tumor therapy, photodynamic
