17054-49-8

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 100-52-7 benzaldehyde 
• 17054-48-7 (1RS,2SR)-2-(3,4-dihydro-1H-isoquinolin-2-yl)-1,2-diphenyl-ethanol 
• 103-30-0 (E)-1,2-diphenyl-ethene 

Relevant academic research and scientific papers

Oxygen transfer reactions from an oxaziridinium tetrafluoroborate salt to olefins

Oxaziridinium 5 efficiently epoxidises olefins. It reacts as an electrophilic reagent and does not transfer its oxygen to deactivated double-bonds or carbonyl functions. Epoxidation of cyclic allylic acetates shows a remarkable diastereoselectivity leading to the syn isomer. We propose that the epoxidation reaction proceeds through a one-step process.

Investigations concerning the benzylation of tetrahydroisoquinolines with benzaldehyde and substituted benzaldehyde (Rugheimer-Burrows-reaction)

The condensation of piperidine and tetrahydroisoquinoline derivatives with benzaldehyde leading to the corresponding benzylated aromatic systems is a multistep reaction for which different mechanisms are discussed. Isolation and characterization of the following intermediates and side products are helpful to explain parts of the sequence.