170638-52-5Relevant academic research and scientific papers
Efficient Method for the Preparation of Nucleoside Phosphorofluoridates and Nucleoside Phosphorofluoridothioates
Bollmark, Martin,Zain, Rula,Stawinski, Jacek
, p. S68 - S71 (2007/10/03)
Dinucleoside H-phosphonates and nucleoside H-phosphonothioates can be efficiently transformed to the fluorophosphate and fluorothiophosphate diester derivatives via iodine promoted oxidation in the presence of fluoride anions.An analogous oxidation of the
A facile access to nucleoside phosphorofluoridate, nucleoside phosphorofluoridothioate, and nucleoside phosphorofluoridodithioate monoesters
Bollmark, Martin,Stawinski, Jacek
, p. 5739 - 5742 (2007/10/03)
Oxidation of H-phosphonate, H-phosphonothioate, or H-phosphonodithioate monoesters with iodine in pyridine in the presence of trimethylsilyl chloride, followed by addition of triethylamine trishydrofluoride (TAF) furnished rapid and quantitative formation of the corresponding phosphorofluoridate, phosphorofluoridothioate, or phosphorofluoridodithioate monoesters.
Nucleoside H-phosphonates. 15. Preparation of nucleoside H-phosphonothioate monoesters from the corresponding nucleoside H-phosphonates
Zain,Stromberg,Stawinski
, p. 8241 - 8244 (2007/10/03)
A convenient method for the preparation of nucleoside 3'-H-phosphonothioate monoesters from suitably protected nucleoside 3'-H-phosphonates has been developed. It consists of activation of nucleoside H-phosphonates with pivaloyl chloride in the presence of a limited amount of a base followed by treatment with 1,1,1,3,3,3-hexamethyldisilathiane (HMDST).
Conversion of nucleoside H-phosphonate monoesters to the corresponding H- phosphonothioates. 31P NMR studies
Stawinski,Zain
, p. 711 - 714 (2007/10/02)
31P NMR Studies on the conversion of nucleoside H-phosphonate monoesters into the corresponding H-phosphonothioates revealed that the key intermediate, the nucleoside trimethylsilyl pivaloyl phosphite 3, may undergo under the reaction condition
