130288-81-2

Upstream product

• 66470-81-3 tris(1,1,1,3,3,3-hexafluoroisopropyl)phosphite 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 13325-10-5 4-Aminobutanol 
• 102987-83-7 5′-O-(4,4′-dimethoxytrityl)thymidine-3′-O-[2-cyanoethyl]phosphonate 
• 4048-33-3 6-amino-1-hexanol 
• 128981-11-3 C₃₅H₃₅N₈O₇P 
• 129624-17-5 5'-O-dimethoxytritylthymidine 3'-hydrogenphosphonodithioate 
• 156-87-6 propan-1-ol-3-amine 
• 141-43-5 ethanolamine 
• 120104-57-6 bis(1,1,1,3,3,3-hexafluoropropan-2-yl) hydrogen phosphite 

Downstream Products

• 157793-51-6 3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl ethyl phosphonate 
• 114797-74-9 C₃₆H₃₆N₃O₉P 
• 908248-49-7 C₄₆H₅₃N₄O₁₀PSi 
• 307309-80-4 C₄₀H₄₂Cl₃N₂O₉PSi 
• 170638-52-5 5'-O-(dimethoxytrityl)thymidin-3'-yl (trimethylsilyl)-H-phosphonate 
• 182245-71-2 C₃₇H₄₉N₂O₉PSi₂ 
• 180475-92-7 2,4,6-Trichlorophenyl 5'-O-dimethoxytritylthymidin-3'-yl phosphonate 
• 102987-86-0 C₄₈H₄₉N₄O₁₄P 

Relevant academic research and scientific papers

A Convenient Approach to the Synthesis of Deoxyribonucleoside-3'-hydrogen Phosphonates via Bis(1,1,1,3,3,3-hexafluoro-2-propyl) Phosphonate Intermediate

Transesterification of a new reagent, bis(1,1,1,3,3,3-hexafluoro-2-propyl)phosphonates was found to be very effective for the preparation of deoxyribonucleoside-3'-hydrogen phosphonates.The yields of deoxyribooligonucleotides by the H-phosphonate method o

Studies on reactions of nucleoside H-phosphonates with bifunctional reagents. Part 3. Further studies on transesterification of nucleoside H- phosphonate diesters with amino alcohols

Reactions of 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 2-cyanoethyl phosphonate with alcohols, amines and amino alcohols in pyridine are described. Transesterification was found to be faster than β-elimination of 2-cyanoethyl group.

Oxidative and nonoxidative formation of internucleotide linkages

Activation of nucleoside 3'-hydrogenphosphonodithioates with iodine in the presence of nucleosides and amines yields dinucleoside phosphorodithioates and nucleoside phosphorodithioamidates, respectively. Similar activation of nucleoside 3'-methylphosphono

USE OF NEW PHOSPHONYLATING AND COUPLING AGENTS IN THE SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES VIA THE H-PHOSPHONATE APPROACH

Tris(1,1,1,3,3,3-hexafluoro-2-propyl) phosphite was used as a phosphonylating reagent for the preparation of nucleoside 3'-H-phosphonate units.The use of a new coupling reagent, 1,3-dimethyl-2-chloro-imidazolinium chloride (DMCI) for the internucleotidic H-phosphonate bond formation via the H-phosphonate approach is also discussed in detail.

A CONVENIENT METHOD FOR THE SYNTHESIS OF DEOXYRIBONUCLEOSIDE 3'-HYDROGENPHOSPHONATES

Appropriately protected 5'-O-dimethoxytrityldeoxyribonucleoside derivatives were converted to the corresponding 3'-hydrogenphosphonates by treatment with phosphinic acid in the presence of mesitylenedisulfonyl chloride via an oxidative phosphonylation process.