170649-26-0Relevant articles and documents
Total synthesis of virgatolide B
Hume, Paul A.,Furkert, Daniel P.,Brimble, Margaret A.
supporting information, p. 4588 - 4591 (2013/09/24)
The first total synthesis of the benzannulated spiroketal virgatolide A is presented. Key features include sp3-sp2 Suzuki coupling of an enantiomerically enriched β-trifluoroboratoamide and an aryl bromide, regioselective intramolecular carboalkoxylation, and a 1,3-anti-selective Mukaiyama aldol reaction followed by global deprotection/cyclization with regioselectivity governed by internal hydrogen bonding.
Natural product-guided synthesis of a spiroacetal collection reveals modulators of tubulin cytoskeleton integrity
Barun, Okram,Kumar, Kamal,Sommer, Stefan,Langerak, Anette,Mayer, Thomas U.,Mueller, Oliver,Waldmann, Herbert
, p. 4773 - 4788 (2007/10/03)
The spiro[5.5]ketal moiety forms the underlying structural skeleton of numerous biologically active natural products. Since simplified but characteristic spiroketals derived from the parent natural products retain biological activity, the spiro[5.5]ketal
An efficient method for the p-methoxybenzylation of hydroxy groups with 2-(4-methoxybenzyloxy)-3-nitropyridine
Nakano, Masakazu,Kikuchi, Wataru,Matsuo, Jun-Ichi,Mukaiyama, Teruaki
, p. 424 - 425 (2007/10/03)
2-(4-Methoxybenzyloxy)-3-nitropyridine (PMBONPy), easily prepared from 2-chloro-3-nitropyridine and p-methoxybenzyl (PMB) alcohol, reacts with various types of hydroxy groups in the presence of a catalytic amount of trimethylsilyl triflate (Me3SiOTf) to give the corresponding PMB ethers in high yields under mild conditions.
Solution and solid phase p-alkoxybenzylation of alcohols under neutral conditions
Hanessian, Stephen,Huynh, Hoan Khai
, p. 671 - 674 (2007/10/03)
Primary, secondary, and tertiary alcohols can be converted to p- methoxybenzyl ethers under neutral conditions in the presence of a variety of commonly used functional and protective groups. The method can be adapted to solid phase on a Wang resin.
An Efficient Synthesis of Radicinin Analogues
Eh, Marcus,Schomburg, Dietmar,Schicht, Kathrin,Kalesse, Markus
, p. 8983 - 8992 (2007/10/02)
We described herein an enantio- and diastereoselective total synthesis of two radicinin analogues 13 and 14. 13 has been subjected to biological tests, exhibiting the lowest toxicity of all radicinin analogues that have been investigated to date and it de
