170649-28-2

Upstream product

• 170649-27-1 (3S)-3-<(p-methoxybenzyl)-oxy>-butan-1-ol 
• 56816-01-4 ethyl (S)-3-hydroxybutyrate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 847049-72-3 1-methoxy-4-{[(2S)-pent-4-en-2-yloxy]methyl}benzene 
• 350848-03-2 methyl (S)-3-(4-methoxybenzyloxy)butanoate 
• 170649-26-0 (S)-3-(4-Methoxy-benzyloxy)-butyric acid ethyl ester 

Downstream Products

• 603038-88-6 C₁₃H₁₆Br₂O₂ 
• 1395502-34-7 C₁₅H₂₀O₄ 
• 1395502-75-6 C₂₆H₅₀O₅Si₂ 
• 1395502-76-7 C₂₆H₄₈O₅Si₂ 
• 1395502-35-8 C₃₁H₅₆O₆Si₂ 
• 1395502-77-8 C₂₉H₅₄O₅Si₂ 
• 1450741-63-5 (S)-5,7-bis((benzyloxy)methoxy)-6-((2S,5R,7S)-5-hydroxy-7-((4-methoxybenzyl)oxy)-2-methyl-3-oxooctyl)-3-((S)-1-hydroxyethyl)isobenzofuran-1(3H)-one 
• 1450741-65-7 C₄₆H₅₈O₁₁Si 
• 1610702-32-3 (2S,5R,7S)-1-(2,6-bis((benzyloxy)methoxy)-4-((E)-prop-1-en-1-yl)phenyl)-5-hydroxy-7-((4-methoxybenzyl)oxy)-2-methyloctan-3-one 
• 1610702-16-3 (2S,5R,7S)-1-(2,6-bis(ethoxymethoxy)phenyl)-5-hydroxy-7-((4-methoxybenzyl)oxy)-2-methyloctan-3-one 

Relevant academic research and scientific papers

Total synthesis of virgatolide B

The first total synthesis of the benzannulated spiroketal virgatolide A is presented. Key features include sp3-sp2 Suzuki coupling of an enantiomerically enriched β-trifluoroboratoamide and an aryl bromide, regioselective intramolecular carboalkoxylation, and a 1,3-anti-selective Mukaiyama aldol reaction followed by global deprotection/cyclization with regioselectivity governed by internal hydrogen bonding.

Synthesis and structure of two new mycolactones isolated from M. ulcerans subsp. shinshuense

Two new mycolactones, mycolactones S1 and S2, were isolated from culture agar of Mycobacterium ulcerans subsp. shinshuense. Their structures were established in a three-step procedure: (1) probable structures were speculated from MS analysis; (2) candidates were synthesized; (3) HPLC profiles were established for identification of the natural products. Newly isolated mycolactones correspond to the oxidized forms of mycolactone A/B, the causative toxin of Buruli ulcer, isolated from Mycobacterium ulcerans.

Asymmetric synthesis of (+)-chloriolide

An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macr

Enantioselective total synthesis of aspergillide C

(Chemical Equation Presented) The first enantioselective total synthesis of aspergillide C, a cytotoxic 14-membered macrotide isolated from the marine-derived fungus Aspergillus ostianus, has been accomplished from a commercially available chiral glycidol

Natural product-guided synthesis of a spiroacetal collection reveals modulators of tubulin cytoskeleton integrity

The spiro[5.5]ketal moiety forms the underlying structural skeleton of numerous biologically active natural products. Since simplified but characteristic spiroketals derived from the parent natural products retain biological activity, the spiro[5.5]ketal

MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS

The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.

An Efficient Synthesis of Radicinin Analogues

We described herein an enantio- and diastereoselective total synthesis of two radicinin analogues 13 and 14. 13 has been subjected to biological tests, exhibiting the lowest toxicity of all radicinin analogues that have been investigated to date and it de