170686-10-9

Basic information

• Product Name: N-[5-[2-[1(R)-[4-(Difluoromethoxy)phenyl]-2-phenylethylamino]-1(R)-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide
• Synonyms: BMS-196085
• CAS NO: 170686-10-9
• Molecular Formula: C₂₄H₂₆F₂N₂O₅S
• Molecular Weight: 492.54602
• Mol File: 170686-10-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[5-[2-[1(R)-[4-(Difluoromethoxy)phenyl]-2-phenylethylamino]-1(R)-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[5-[2-[1(R)-[4-(Difluoromethoxy)phenyl]-2-phenylethylamino]-1(R)-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide(170686-10-9)
• EPA Substance Registry System: N-[5-[2-[1(R)-[4-(Difluoromethoxy)phenyl]-2-phenylethylamino]-1(R)-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide(170686-10-9)

Safety Data

• Hazardous Substances Data: 170686-10-9(Hazardous Substances Data)

Upstream product

• 170688-14-9 N-(2-Benzyloxy-5-{(R)-2-[(R)-1-(4-difluoromethoxy-phenyl)-2-phenyl-ethylamino]-1-triethylsilanyloxy-ethyl}-phenyl)-methanesulfonamide 
• 948576-10-1 (R)-1-(4-Difluoromethoxy-phenyl)-2-phenyl-ethylamine 
• 73960-07-3 4-difluoromethoxybenzaldehyde 

Relevant articles and documents

BMS-196085: A potent and selective full agonist of the human β3 adrenergic receptor

A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human β3 adrenergic receptor agonist activity. SAR studies led to the identification of BMS-196085 (25), a potent β3 full agonist (Ki=21 nM, 95% activation) with partial agonist (45%) activity at the β1 receptor. Based on its desirable in vitro and in vivo properties, BMS-196085 was chosen for clinical evaluation.