170698-16-5

Upstream product

• 94224-61-0 o-(p-methoxybenzoyl)benzoyl chloride 
• 100-46-9 benzylamine 
• 73178-23-1 N-benzyl-2-iodobenzamide 
• 104-47-2 p-methoxybenzylnitrile 
• 1151-15-1 2-(4-methoxybenzoyl)benzoic acid 

Downstream Products

• 170698-24-5 4-(4-methoxyphenyl)-3-phenyl-2H-isoquinolin-1-one 
• 170698-26-7 1-chloro-4-(4-methoxyphenyl)-3-phenylisoquinoline 
• 93119-94-9 3-(p-methoxyphenyl)-4-phenyl-1-isoquinolone 

Relevant academic research and scientific papers

Copper-catalysed synthesis of 3-hydroxyisoindolin-1-ones from benzylcyanide 2-iodobenzamides

An efficient one-pot two-step sequential reaction for the synthesis of biologically active 3-hydroxyisoindolin-1-one derivatives from 2-iodobenzamide derivatives and various substituted benzyl cyanides in the presence of CuCl and cesium carbonate in DMSO is reported. Furthermore, 3-hydroxyisoindolinone derivatives possessing bromo substituents were obtained from 2-iodobenzamide and 2-bromobenzyl cyanide substrates in two steps. Benzyl cyanide has been successfully used for the first time as a benzoyl synthon for the synthesis of 3-hydroxyisoindolin-1-ones. Interestingly, the mechanism of formation of 3-hydroxyisoindolin-1-ones is a novel pathway that involves carbon degradation followed by ring contraction.

SYNTHESIS OF 1-SUBSTITUTED 3,4-DIARYLISOQUINOLINE DERIVATIVES

3,4-Diaryl-2H-isoquinolin-2-ones and corresponding 1-chloro derivatives were easily prepared in a way involving i) condensation of 2-aroylbenzyl chlorides with arylmethylamines; ii) treatment of the resulting 1-aryl-N-1-hydroxyarylmethylisoindol-3-ones wi