1151-15-1

Basic information

• Product Name: 2-(4-METHOXY-BENZOYL)-BENZOIC ACID
• Synonyms: TIMTEC-BB SBB006969;2-(4-METHOXYBENZOYL)BENZENECARBOXYLIC ACID;2-(4-METHOXY-BENZOYL)-BENZOIC ACID;Benzoic acid, 2- (4-methoxybenzoyl)-;o-(p-anisoyl)benzoic acid;4'-(Hydroxymethyl)benzophenone-2-carboxylic acid;2-[(4-Methoxyphenyl)carbonyl]benzoic acid, 2-(4-Methoxybenzoyl)benzoic acid
• CAS NO: 1151-15-1
• Molecular Formula: C₁₅H₁₂O₄
• Molecular Weight: 256.25
• Mol File: 1151-15-1.mol
• Article Data: 32

Chemical Properties

• Melting Point: 147-148
• Boiling Point: 359.49°C (rough estimate)
• Flash Point: 183.5 °C
• Appearance: /
• Density: 1.2390 (rough estimate)
• Vapor Pressure: 6.25E-10mmHg at 25°C
• Refractive Index: 1.4872 (estimate)
• Storage Temp.: 2-8°C
• PKA: 3.34±0.36(Predicted)
• CAS DataBase Reference: 2-(4-METHOXY-BENZOYL)-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXY-BENZOYL)-BENZOIC ACID(1151-15-1)
• EPA Substance Registry System: 2-(4-METHOXY-BENZOYL)-BENZOIC ACID(1151-15-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1151-15-1(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxy-benzoyl)-benzoic acid is a chemical compound with the molecular formula C15H12O4. It is a derivative of benzoic acid and contains a benzoyl group and a methoxy group. 2-(4-METHOXY-BENZOYL)-BENZOIC ACID is commonly used in the production of pharmaceuticals, particularly in the synthesis of antifungal agents and other biologically active compounds. It can also be used as a reagent in organic synthesis and as a chemical intermediate in various industrial processes. The presence of the benzoyl and methoxy groups in 2-(4-Methoxy-benzoyl)-benzoic acid confers specific chemical and biological properties that make it an important component in the development of diverse products and applications.

InChI:InChI=1/C15H12O4/c1-19-11-8-6-10(7-9-11)14(16)12-4-2-3-5-13(12)15(17)18/h2-9H,1H3,(H,17,18)

Upstream product

• 85-44-9 phthalic anhydride 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 71-43-2 benzene 
• 7446-70-0 aluminium trichloride 
• 100-66-3 methoxybenzene 
• 98-95-3 nitrobenzene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 19312-06-2 4,5-dihydro-4,4-dimethyl-2-phenoxazole 
• 17763-70-1 methyl 2-(trifluoromethylsulfonyloxy)benzoate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 860358-60-7 5,10-bis-(4-methoxyphenyl)-indeno[2,1-a]indene 
• 64-19-7 acetic acid 
• 53786-92-8 3-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one 
• 85-57-4 2-(4-hydroxy-benzoyl)-benzoic acid 

Downstream Products

• 40893-30-9 3-methoxy-3-(4-methoxy-phenyl)-3H-isobenzofuran-1-one 
• 42138-12-5 3-(4-hydroxy-phenyl)-3-(4-methoxy-phenyl)-3H-isobenzofuran-1-one 
• 84940-24-9 3,4-dihydro-10b-(p-methoxyphenyl)-2H-<1,3>oxazino<2,3-a>isoindol-6(10bH)-one 
• 175857-55-3 N-diphenylphosphinoylmethyl-N-methyl-2-(4-methoxybenzoyl)benzamide 
• 120-12-7 anthracene 
• 74-87-3 methylene chloride 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 108-95-2 phenol 
• 65-85-0 benzoic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 153397-52-5 3-hydroxy-3-(4-methoxyphenyl)-2-methylisoindolin-1-one 
• 57591-01-2 (2-(hydroxymethyl)phenyl)(4-methoxyphenyl)methanol 
• 1055981-47-9 (S)-2-(4'-methoxybenzoyl)-N-(α-phenylethyl)benzamide 
• 5449-71-8 methyl 2-(4-methoxybenzoyl)benzoate 

Relevant articles and documents

Direct Synthesis of γ-Substituted Phthalides Via ortho-Aryl Benzoic Acid Mediated Benzyl Radical Cyclization

Direct synthesis of γ-substituted phthalids from related ortho-aryl benzoic acids with 48-85% yield are covered. The direct oxidation in the presence of peroxydisulphate-copper (II) chloride in aqueous medium was applied. The reaction is highly regioselective and leads exclusively to γ-butyrolactone, through very stable benzylic radical intermediate.

Direct synthesis of γ-substituted phthalides by cyclization of benzyl radicals generated from o-(arylmethyl)benzoic acids

Direct oxidation of o-(arylmethyl)benzoic acids with sodium peroxysulfate-copper(II) chloride in water yields γ-substituted phthalides. The reaction is highly regioselective, and the corresponding γ-butyro-lactones are the only products formed through intermediate stable arylmethyl radicals.

Synthesis and conformational properties of 2,2′-dihydroxy-9,9′-bianthryl

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Construction of an isoquinolinone framework from carboxylic-ester-directed umpolung ring opening of methylenecyclopropanes

An interesting type of reaction involving functionalized methylenecyclopropanes (MCPs) has been revealed. Here, a nucleophilic attack of an anionic species onto a partially polarity-reversed MCP was realized by treating a neighbouring carboxylic ester tethered to the MCP and amine with KHMDS to realize an umpolung ring opening of the MCP. This work established an operationally convenient protocol for the rapid construction of isoquinolinone frameworks. This journal is

Metal-Free Arylation-Lactonization Sequence of γ-Alkenoic Acids Using Anilines as Aryl Radical Precursors

The presence of salicylic acid (10 mol-%) and H2O (10 equiv.) significantly improves the arylation-lactonization sequence of γ-alkenoic acids with in situ formed diazonium salts (from bench stable anilines). The reaction is finished in less than 5 h without thermal or photochemical activation, giving access to a variety of γ,γ-disubstituted butyrolactones. The protocol is user-friendly and can be used at gram-scale or adapted to transform alkenols into phthalanes. Control experiments revealed that aryl radicals participate in the reaction and a plausible mechanism is proposed to include this and other mechanistic investigations, for the catalyzed and the background reaction.