170737-24-3

Basic information

• Product Name: tert-butyl 4-(6-cyano-2-naphthalenecarboxamido)phenoxyacetate
• Synonyms: tert-butyl 4-(6-cyano-2-naphthalenecarboxamido)phenoxyacetate
• CAS NO: 170737-24-3
• Molecular Weight: 402.45
• Mol File: 170737-24-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(6-cyano-2-naphthalenecarboxamido)phenoxyacetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(6-cyano-2-naphthalenecarboxamido)phenoxyacetate(170737-24-3)
• EPA Substance Registry System: tert-butyl 4-(6-cyano-2-naphthalenecarboxamido)phenoxyacetate(170737-24-3)

Safety Data

• Hazardous Substances Data: 170737-24-3(Hazardous Substances Data)

Upstream product

• 145369-29-5 trifluoromethanesulfonic acid 6-cyano-naphthalen-2-yl ester 
• 20768-14-3 (4-nitrophenoxy)acetic acid tert-butyl ester 
• 5088-91-5 6-cyano-naphthalene-2-carboxylic acid methyl ester 
• 52927-22-7 6-cyano-2-naphthol 
• 5159-60-4 6-cyano-naphthalene-2-carboxylic acid 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 100-02-7 4-nitro-phenol 
• 15231-91-1 6-bromo-naphthalen-2-ol 

Relevant articles and documents

Preparation and pharmacological evaluation of novel glycoprotein (Gp) IIb/IIIa antagonists. 1. The selection of naphthalene derivatives

The synthesis and design using molecular modeling techniques for non- peptide, low molecular weight novel fibrinogen receptor (glycoprotein IIb/IIIa: Gp IIb/IIIa) antagonists, is reported. We used a highly potent serine protease inhibitor, Nafamostat, having an amidinonaphthyl unit as the starting compound. The compounds 4-(6-amidino-2- naphthylaminocarbonyl)phenoxyacetic acid (5a) and 4-(6-amidino-2- naphthalenecarboxamido)phenoxyacetic acid (5b) inhibited adenosin-5'- diphospate (ADP)-induced aggregation of human platelet-rich plasma (PRP) with IC50 values of 0,05 and 0.07 μM, respectively, and had lost their ability to inhibit a variety of serine proteases, including thrombin, factor Xa, plasmin and trypsin.