1708-59-4Relevant academic research and scientific papers
Cyclization of benzyne-tethered alkyllithiums: Preparation of 3-substituted benzocyclobutenes and 5-substituted tetralins
Bailey, William F.,Longstaff, Sarah C.
, p. 6899 - 6901 (1999)
A five-step, one-pot preparation of isomerically pure 3-substituted benzocyclobutenes or 5-substituted tetralins in 20-40% yield from the appropriate α-(2-fluorophenyl)-ω-iodoalkane, involving generation and subsequent 4-or 6-exo cyclization of a benzyne-tethered alkyllithium, is described.
Bicycloocta-1,3,5-triene: 2-Mono- and 2,5-Disubstituted Derivatives via Highly Regioselective Lithiation of Its Cr(CO)3 Complex and via Reductive Silylation / Oxidation
Kuendig, E. Peter,Perret, Celia,Rudolph, Bruno
, p. 1970 - 1979 (1990)
Treatment of 6-(bicycloocta-1,3,5-triene)>tricarbonylchromium(0) (2) with BuLi or lithium 2,2,6,6-tetramethylpiperidinide (TMPLi) gives rise to a highly regioselective deprotonation at C(2).Subsequent reaction with electrophiles (6 exa
