170850-45-0

Basic information

• Product Name: 6-P-TOLYLPYRIDIN-3-YLAMINE
• Synonyms: 6-(p-Tolyl);6-P-TOLYLPYRIDIN-3-YLAMINE;AKOS BAR-2341;6-(4-methylphenyl)pyridin-3-amine;6-P-TOLYLPYRIDIN-3-YLAMINE, 95+%;6-(p-tolyl)pyridin-3-aMine
• CAS NO: 170850-45-0
• Molecular Formula: C₁₂H₁₂N₂
• Molecular Weight: 184.24
• Mol File: 170850-45-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 351.084 °C at 760 mmHg
• Flash Point: 193.186 °C
• Appearance: /
• Density: 1.107 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.68±0.25(Predicted)
• CAS DataBase Reference: 6-P-TOLYLPYRIDIN-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-P-TOLYLPYRIDIN-3-YLAMINE(170850-45-0)
• EPA Substance Registry System: 6-P-TOLYLPYRIDIN-3-YLAMINE(170850-45-0)

Safety Data

• Hazardous Substances Data: 170850-45-0(Hazardous Substances Data)

Usage

General Description

6-P-Tolylpyridin-3-ylamine is a chemical compound with the molecular formula C13H13N3. It is an aromatic amine with a pyridine core and a tolyl group. 6-P-TOLYLPYRIDIN-3-YLAMINE is commonly used as a building block or intermediate in the synthesis of various pharmaceuticals and organic compounds. It is also known for its potential use in the development of organic light-emitting diodes (OLEDs) due to its electron transport properties. 6-P-Tolylpyridin-3-ylamine is a versatile chemical that has multiple applications in the field of organic chemistry and material science.

InChI:InChI=1/C12H12N2/c1-9-2-4-10(5-3-9)12-7-6-11(13)8-14-12/h2-8H,13H2,1H3

Upstream product

• 131941-26-9 2-(4-methylphenyl)-5-nitropyridine 
• 4487-59-6 2-bromo-5-nitropyridine 
• 5720-05-8 4-methylphenylboronic acid 
• 106-38-7 para-bromotoluene 
• 2127-09-5 2-mercapto-5-nitropyridine 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 13534-97-9 6-bromopyridine-3-amine 

Downstream Products

• 1404112-26-0 N-(6-p-tolylpyridin-3-yl)cyclopropanecarboxamide 
• 119811-95-9 2-(4-methylphenyl)-5-trifluoromethylpyridine 

Relevant articles and documents

Heterocyclic Allylsulfones as Latent Heteroaryl Nucleophiles in Palladium-Catalyzed Cross-Coupling Reactions

Heterocyclic sulfinates are effective reagents in palladium-catalyzed coupling reactions with aryl and heteroaryl halides, often providing high yields of the targeted biaryl. However, the preparation and purification of complex heterocylic sulfinates can be problematic. In addition, sulfinate functionality is not tolerant of the majority of synthetic transformations, making these reagents unsuitable for multistep elaboration. Herein, we show that heterocyclic allylsulfones can function as latent sulfinate reagents and, when treated with a Pd(0) catalyst and an aryl halide, undergo deallylation, followed by efficient desulfinylative cross-coupling. A broad range of allyl heteroarylsulfones are conveniently prepared, using several complementary routes, and are shown to be effective coupling partners with a variety of aryl and heteroaryl halides. We demonstrate that the allylsulfone functional group can tolerate a range of standard synthetic transformations, including orthogonal C- and N-coupling reactions, allowing multistep elaboration. The allylsulfones are successfully coupled with a variety of medicinally relevant substrates, demonstrating their applicability in demanding cross-coupling transformations. In addition, pharmaceutical agents crizotinib and etoricoxib were prepared using allyl heteroaryl sulfone coupling partners, further demonstrating the utility of these new reagents.

Structure-activity relationship study of E6 as a novel necroptosis inducer

Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations.

AGENT FOR TREATMENT OF EYE DISEASES

The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharma