170850-45-0

Basic information

• Product Name: 6-P-TOLYLPYRIDIN-3-YLAMINE
• Synonyms: 6-(p-Tolyl);6-P-TOLYLPYRIDIN-3-YLAMINE;AKOS BAR-2341;6-(4-methylphenyl)pyridin-3-amine;6-P-TOLYLPYRIDIN-3-YLAMINE, 95+%;6-(p-tolyl)pyridin-3-aMine
• CAS NO: 170850-45-0
• Molecular Formula: C₁₂H₁₂N₂
• Molecular Weight: 184.24
• Mol File: 170850-45-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 351.084 °C at 760 mmHg
• Flash Point: 193.186 °C
• Appearance: /
• Density: 1.107 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.68±0.25(Predicted)
• CAS DataBase Reference: 6-P-TOLYLPYRIDIN-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-P-TOLYLPYRIDIN-3-YLAMINE(170850-45-0)
• EPA Substance Registry System: 6-P-TOLYLPYRIDIN-3-YLAMINE(170850-45-0)

Safety Data

• Hazardous Substances Data: 170850-45-0(Hazardous Substances Data)

Usage

Description

6-P-Tolylpyridin-3-ylamine, with the molecular formula C13H13N3, is an aromatic amine characterized by a pyridine core and a tolyl group. This versatile chemical compound is recognized for its applications in organic chemistry and material science, particularly as a building block or intermediate in the synthesis of pharmaceuticals and organic compounds. Its electron transport properties also make it a candidate for the development of organic light-emitting diodes (OLEDs).

Uses

Used in Pharmaceutical Synthesis:
6-P-Tolylpyridin-3-ylamine is utilized as a key intermediate in the production of various pharmaceuticals. Its unique structure allows for the creation of new drug molecules with potential therapeutic applications.
Used in Organic Compounds Synthesis:
6-P-TOLYLPYRIDIN-3-YLAMINE serves as a building block in the synthesis of a range of organic compounds, contributing to the development of new materials and chemical products.
Used in Material Science:
6-P-Tolylpyridin-3-ylamine is applied in material science for its electron transport properties, which are valuable in the advancement of technologies such as organic light-emitting diodes (OLEDs), where it can enhance the performance and efficiency of these devices.
Used in OLED Development:
In the application industry of display technology, 6-P-Tolylpyridin-3-ylamine is used as a component in the development of organic light-emitting diodes. Its role in electron transport is crucial for improving the performance and efficiency of OLEDs, leading to better display capabilities and energy savings.

InChI:InChI=1/C12H12N2/c1-9-2-4-10(5-3-9)12-7-6-11(13)8-14-12/h2-8H,13H2,1H3

Upstream product

• 106-38-7 para-bromotoluene 
• 2127-09-5 2-mercapto-5-nitropyridine 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 5720-05-8 4-methylphenylboronic acid 
• 13534-97-9 6-bromopyridine-3-amine 
• 4487-59-6 2-bromo-5-nitropyridine 
• 131941-26-9 2-(4-methylphenyl)-5-nitropyridine 

Downstream Products

• 1404112-26-0 N-(6-p-tolylpyridin-3-yl)cyclopropanecarboxamide 
• 119811-95-9 2-(4-methylphenyl)-5-trifluoromethylpyridine 

Relevant articles and documents

Heterocyclic Allylsulfones as Latent Heteroaryl Nucleophiles in Palladium-Catalyzed Cross-Coupling Reactions

Heterocyclic sulfinates are effective reagents in palladium-catalyzed coupling reactions with aryl and heteroaryl halides, often providing high yields of the targeted biaryl. However, the preparation and purification of complex heterocylic sulfinates can be problematic. In addition, sulfinate functionality is not tolerant of the majority of synthetic transformations, making these reagents unsuitable for multistep elaboration. Herein, we show that heterocyclic allylsulfones can function as latent sulfinate reagents and, when treated with a Pd(0) catalyst and an aryl halide, undergo deallylation, followed by efficient desulfinylative cross-coupling. A broad range of allyl heteroarylsulfones are conveniently prepared, using several complementary routes, and are shown to be effective coupling partners with a variety of aryl and heteroaryl halides. We demonstrate that the allylsulfone functional group can tolerate a range of standard synthetic transformations, including orthogonal C- and N-coupling reactions, allowing multistep elaboration. The allylsulfones are successfully coupled with a variety of medicinally relevant substrates, demonstrating their applicability in demanding cross-coupling transformations. In addition, pharmaceutical agents crizotinib and etoricoxib were prepared using allyl heteroaryl sulfone coupling partners, further demonstrating the utility of these new reagents.

Structure-activity relationship study of E6 as a novel necroptosis inducer

Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations.

NAPHTHALENE DERIVATIVE

The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) (R is as defined in the description) or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.