131941-26-9

Basic information

• Product Name: 5-nitro-2-(p-tolyl)pyridine
• Synonyms: 5-nitro-2-(p-tolyl)pyridine
• CAS NO: 131941-26-9
• Molecular Formula: C₁₂H₁₀N₂O₂
• Molecular Weight: 214.22
• Mol File: 131941-26-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-nitro-2-(p-tolyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-nitro-2-(p-tolyl)pyridine(131941-26-9)
• EPA Substance Registry System: 5-nitro-2-(p-tolyl)pyridine(131941-26-9)

Safety Data

• Hazardous Substances Data: 131941-26-9(Hazardous Substances Data)

Upstream product

• 14150-94-8 3,5-dinitro-1-methyl-2-pyridone 
• 122-00-9 para-methylacetophenone 
• 4487-59-6 2-bromo-5-nitropyridine 
• 5720-05-8 4-methylphenylboronic acid 
• 4548-45-2 2-chloro-5-nitropyridine 
• 5142-75-6 tri(p-tolyl)bismuth 
• 106-38-7 para-bromotoluene 
• 2127-09-5 2-mercapto-5-nitropyridine 

Downstream Products

• 170850-45-0 3-amino-6-(4-methylphenyl)pyridine 
• 1404112-26-0 N-(6-p-tolylpyridin-3-yl)cyclopropanecarboxamide 

Relevant articles and documents

Heterocyclic Allylsulfones as Latent Heteroaryl Nucleophiles in Palladium-Catalyzed Cross-Coupling Reactions

Heterocyclic sulfinates are effective reagents in palladium-catalyzed coupling reactions with aryl and heteroaryl halides, often providing high yields of the targeted biaryl. However, the preparation and purification of complex heterocylic sulfinates can be problematic. In addition, sulfinate functionality is not tolerant of the majority of synthetic transformations, making these reagents unsuitable for multistep elaboration. Herein, we show that heterocyclic allylsulfones can function as latent sulfinate reagents and, when treated with a Pd(0) catalyst and an aryl halide, undergo deallylation, followed by efficient desulfinylative cross-coupling. A broad range of allyl heteroarylsulfones are conveniently prepared, using several complementary routes, and are shown to be effective coupling partners with a variety of aryl and heteroaryl halides. We demonstrate that the allylsulfone functional group can tolerate a range of standard synthetic transformations, including orthogonal C- and N-coupling reactions, allowing multistep elaboration. The allylsulfones are successfully coupled with a variety of medicinally relevant substrates, demonstrating their applicability in demanding cross-coupling transformations. In addition, pharmaceutical agents crizotinib and etoricoxib were prepared using allyl heteroaryl sulfone coupling partners, further demonstrating the utility of these new reagents.

Triarylbismuthanes as threefold aryl-transfer reagents in regioselective cross-coupling reactions with bromopyridines and quinolines

Cross-coupling studies using bromopyridines and bromoquinolines with triarylbismuths as threefold coupling reagents in substoichiometric amounts under Pd-catalysed conditions are disclosed. The reactivity was high with both mono- and dibromopyridyl substrates, and mono- and bis-couplings were carried out regioselectively. A library of monoaryl and diaryl pyridines was formed in high yields. A one-pot strategy provided a simple and straightforward synthesis of both symmetrical and unsymmetrical diarylpyridines. Arylations of 2-bromo- and 3-bromoquinolines were achieved with triarylbismuth reagents. This study demonstrates that triarylbismuths may be used as threefold arylating reagents for the synthesis of aryl pyridines and quinolines through couplings with bromopyridines and bromoquinolines under Pd-catalysed conditions. Copyright

AGENT FOR TREATMENT OF EYE DISEASES

The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharma