170856-81-2Relevant articles and documents
6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D4 receptors
Hodgetts,Kieltyka,Brodbeck,Tran,Wasley,Thurkauf
, p. 3207 - 3213 (2001)
A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]piperazin-1-yl)benzodioxane (2d) had high affinity and selectivity for the D4 dopamine receptor su
Method for efficiently realizing N-alkylation reaction by using cyclic iridium catalyst
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Paragraph 0234-0240, (2020/11/10)
The invention discloses a method for efficiently realizing N-alkylation reaction by using a cyclic iridium catalyst, and belongs to the technical field of pharmaceutical and chemical synthesis. The preparation method comprises the following steps of: taking amines and alcohol compounds as raw materials, a cyclic iridium complex as a catalyst and water or an organic solvent as a reaction medium, heating, stirring and reacting for 12-24 hours under the protection of inert gas, cooling to room temperature after the reaction is finished, carrying out reduced pressure distillation and concentrationto obtain a crude product, and carrying out column chromatography purification to obtain a series of amine compounds. The synthesis method of the amine compound is simple to operate, easily availablein raw materials and low in price; the method is high in reaction efficiency, good in N-alkylation selectivity, good in adaptability to various functional groups, wide in substrate universality and environmentally friendly, is carried out at the gram level, shows the potential of industrially synthesizing the N-alkylamine compound, and has wide application prospects in the fields of medicines, organic synthesis and the like.
"Throwing away" a different ancillary ligand to enhance the catalytic activity at room temperature
Guest, Daniel,Chen, Ming-Tsz,Tizzard, Graham J.,Coles, Simon J.,Turner, Michael Lewis,Navarro, Oscar
supporting information, p. 2200 - 2203 (2015/04/27)
A considerable effort in ligand design for catalysis in recent years has led to remarkable achievements in cross-coupling reactions. In this work, we show that a careful selection of the ancillary ligands that complete the catalyst/precatalyst can provide an extra level of performance. Low loadings of [(IPr)PdCl2(TEA)] {IPr = 1,3-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazole-2-ylidene, TEA = triethylamine} catalyze the Buchwald-Hartwig amination reactions of aryl chlorides at room temperature in excellent yields, without the need for an inert atmosphere to set up or perform the reactions.
