170862-47-2

Upstream product

• 348-57-2 2,4-difluorobromobenzene 
• 170862-46-1 (S)-2-Methyl-3-trityloxy-thiopropionic acid S-pyridin-2-yl ester 
• 116022-79-8 (S)-2-methyl-3-triphenylmethyloxypropionic acid 
• 116021-13-7 (2S)-2-methyl-3-(trityloxy)propionic acid methyl ester 
• 76-83-5 trityl chloride 
• 144025-04-7 (2,4-difluorophenyl)magnesium bromide 

Downstream Products

• 211926-45-3 (2RS,3S)-2-(2,4-difluoro)phenyl-3-methyl-4-triphenylmethyloxy-1,2-epoxybutane 
• 170862-52-9 (2S,3S)-2-(2,4-Difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-4-trityloxy-butan-2-ol 
• 170862-51-8 (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-4-trityloxy-butan-2-ol 
• 170862-54-1 (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-4-triphenylmethyloxy-1,2-butanediol 
• 170862-53-0 (2S,3R)-3-(2,4-difluorophenyl)-2-methyl-4-(1H-1,2,4-triazol-1-yl)butane-1,3-diol 
• 1026233-30-6 Methanesulfonic acid (2R,3S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-methyl-4-trityloxy-butyl ester 
• 170862-56-3 (2R,3R)-3-(2,4-Difluoro-phenyl)-3-hydroxy-2-methyl-4-[1,2,4]triazol-1-yl-butyraldehyde 
• 170862-36-9 (2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile 
• 170862-57-4 (2S)-1-(2,4-difluorophenyl)-3-hydroxy-2-methylpropan-1-one 
• 170862-48-3 (S)-2-(2,4-difluorophenyl)-3-methyl-4-(triphenylmethyloxy)-1,2-butene 

Relevant academic research and scientific papers

Azole antifungal agents, processes for the preparation thereof, and intermediates

A compound represented by the general formula: wherein R1 and R2 denote a halogen atom or hydrogen atoms; R3 means a hydrogen atoms or lower alkyl group; r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic rings, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for -S-, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.

A novel route for chiral synthesis of the triazole antifungal ER-30346

A novel synthetic route to (2S,3S)-2-(2,4-difluorophenyl)-3-hydroxy-2- methyl-4-(1-(1,2,4-triazolyl))butyronitrile (2), an intermediate for the orally active triazole antifungal agent ER-30346, was developed from methyl S-(+)-3-hydroxy-2-methylpropionate,