170862-53-0

Basic information

• Product Name: 1,3-Butanediol, 3-(2,4-difluorophenyl)-2-methyl-4-(1H-1,2,4-triazol-1-yl)-, (2S,3R)-
• CAS NO: 170862-53-0
• Molecular Formula: C13H15F2N3O2
• Molecular Weight: 283.278
• Mol File: 170862-53-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,3-Butanediol, 3-(2,4-difluorophenyl)-2-methyl-4-(1H-1,2,4-triazol-1-yl)-, (2S,3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Butanediol, 3-(2,4-difluorophenyl)-2-methyl-4-(1H-1,2,4-triazol-1-yl)-, (2S,3R)-(170862-53-0)
• EPA Substance Registry System: 1,3-Butanediol, 3-(2,4-difluorophenyl)-2-methyl-4-(1H-1,2,4-triazol-1-yl)-, (2S,3R)-(170862-53-0)

Safety Data

• Hazardous Substances Data: 170862-53-0(Hazardous Substances Data)

Upstream product

• 13292-87-0 dimethyl sulfide borane 
• 166948-49-8 (2R,3R)-3-[3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-3-(1H-1,2,4-triazol-1-yl)]butanoic acid 
• 219872-86-3 propyl (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoate 
• 170862-54-1 (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-4-triphenylmethyloxy-1,2-butanediol 
• 170862-47-2 (S)-1-(2,4-Difluoro-phenyl)-2-methyl-3-trityloxy-propan-1-one 
• 1026233-30-6 Methanesulfonic acid (2R,3S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-methyl-4-trityloxy-butyl ester 
• 211926-45-3 (2RS,3S)-2-(2,4-difluoro)phenyl-3-methyl-4-triphenylmethyloxy-1,2-epoxybutane 
• 170862-48-3 (S)-2-(2,4-difluorophenyl)-3-methyl-4-(triphenylmethyloxy)-1,2-butene 
• 170862-51-8 (2R,3S)-2-(2,4-Difluoro-phenyl)-3-methyl-1-[1,2,4]triazol-1-yl-4-trityloxy-butan-2-ol 

Downstream Products

• 170862-36-9 (2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile 
• 170862-56-3 (2R,3R)-3-(2,4-Difluoro-phenyl)-3-hydroxy-2-methyl-4-[1,2,4]triazol-1-yl-butyraldehyde 

Relevant articles and documents

Carbon analogs of antifungal dioxane-triazole derivatives: Synthesis and in vitro activities

A new series of triazole compounds possessing a carbon atom in place of a sulfur atom were efficiently synthesized and their in vitro antifungal activities were investigated. The carbon analogs showed excellent in vitro activity against Candida, Cryptococcus, and Aspergillus species. The MICs of compound 1c against C. albicans ATCC24433, C. neoformans TIMM1855, and A. fumigatus ATCC26430 were 0.016, 0.016, and 0.125 μg/mL, respectively (MICs of fluconazole: 0.5, >4, and >4 μg/mL; MICs of itraconazole: 0.125, 0.25, and 0.25 μg/mL).

AZOLE COMPOUNDS ENDOWED WITH ANTIMYCOTIC ACTIVITY FOR HUMAN AND VETERINARY USE

Compounds of formula wherein R1 is chloro, fluoro, bromo or trifluoromethyl; R2 is hydrogen, chloro , fluoro, bromo or trifluoromethyl; Z is CH or N; R3, R4 and R5, which are the same or different, are hydrogen or C1-C4 alkyl, with the proviso that R4 is

A novel route for chiral synthesis of the triazole antifungal ER-30346

A novel synthetic route to (2S,3S)-2-(2,4-difluorophenyl)-3-hydroxy-2- methyl-4-(1-(1,2,4-triazolyl))butyronitrile (2), an intermediate for the orally active triazole antifungal agent ER-30346, was developed from methyl S-(+)-3-hydroxy-2-methylpropionate,