170862-48-3Relevant academic research and scientific papers
Azole antifungal agents, processes for the preparation thereof, and intermediates
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Page 120-121, (2010/01/31)
A compound represented by the general formula: wherein R1 and R2 denote a halogen atom or hydrogen atoms; R3 means a hydrogen atoms or lower alkyl group; r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic rings, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for -S-, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.
A novel route for chiral synthesis of the triazole antifungal ER-30346
Kaku, Yumiko,Tsuruoka, Akihiko,Kakinuma, Hiroyuki,Tsukada, Itaru,Yanagisawa, Manabu,Naito, Toshihiko
, p. 1125 - 1129 (2007/10/03)
A novel synthetic route to (2S,3S)-2-(2,4-difluorophenyl)-3-hydroxy-2- methyl-4-(1-(1,2,4-triazolyl))butyronitrile (2), an intermediate for the orally active triazole antifungal agent ER-30346, was developed from methyl S-(+)-3-hydroxy-2-methylpropionate,
