170871-58-6

Basic information

• Product Name: 5'-O-benzoyl-2',3'-dideoxy-3'-phenylselenothymidine
• Synonyms: 5'-O-benzoyl-2',3'-dideoxy-3'-phenylselenothymidine
• CAS NO: 170871-58-6
• Molecular Weight: 485.398
• Mol File: 170871-58-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-O-benzoyl-2',3'-dideoxy-3'-phenylselenothymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-benzoyl-2',3'-dideoxy-3'-phenylselenothymidine(170871-58-6)
• EPA Substance Registry System: 5'-O-benzoyl-2',3'-dideoxy-3'-phenylselenothymidine(170871-58-6)

Safety Data

• Hazardous Substances Data: 170871-58-6(Hazardous Substances Data)

Upstream product

• 70838-44-7 2,3'-anhydro-5'-O-benzoyl-2'-deoxythymidine 
• 645-96-5 Benzeneselenol 
• 50-89-5 thymidine 
• 65-85-0 benzoic acid 

Downstream Products

• 3056-17-5 stavudin 
• 122567-97-9 5′-benzoyl-2′,3′-didehydro-3′-deoxythymidine 

Relevant articles and documents

Efficient transformation of thymidine into 2',3'-didehydro-2',3'-dideoxy- thymidine (D4T) involving opening of a 2,3'-anhydro derivative by phenylselenol

A new, high-yielding method for introduction of the selenophenyl residue at the 3'- position of thymidine is reported. This reaction avoided any strongly basic or reductive reagent, thus allowing the use of benzoate ester as a protective group at O-5'. Further oxidation-elimination sequence followed by basic deprotection afforded 2',3'-didehydro-2',3'- dideoxythymidine (D4T) in 67.5% overall yield from thymidine.