70838-44-7

Usage

Chemical Properties

Colourless solid

Uses

An intermediate in the preparation of anti-HIV pharmaceuticals

Upstream product

• 65-85-0 benzoic acid 
• 50-89-5 thymidine 
• 165047-01-8 5′-benzoyl-3′α-methanesulfonyl-2′α-bromothymidine 
• 165047-02-9 ((2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-(methylsulfonyloxy)-tetrahydrofuran-2-yl)methyl benzoate 

Downstream Products

• 169382-16-5 1-(5-benzoyl-3-bromo-2,3-dideoxy-β-D-erythro-pentofuranosyl)thymine 
• 158868-16-7 5'-O-benzoyl-3'-(2-tetrazolyl)-2',3'-dideoxythymidine 
• 507232-29-3 5-methyl-3'-O-nitro-5'-O-benzoyl-2'-deoxycytidine 
• 507232-26-0 4-(1,2,4-triazolo)-4-deoxy-3'-O-nitro-5'-O-benzoyl-2'-deoxythymidine 
• 167641-89-6 3'-α-C-allenyl-5'-O-benzoyl-2',3'-dideoxythymidine 
• 122621-07-2 1-(5-O-benzoyl-2,3-dideoxy-β-D-glycero-pentofuranosyl)thymine 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 
• 3056-17-5 stavudin 
• 122567-97-9 5′-benzoyl-2′,3′-didehydro-3′-deoxythymidine 

Relevant academic research and scientific papers

Athermal, Chemically Triggered Release of RNA from Thioester Nucleic Acids

An athermal approach to mRNA enrichment from total RNA using a self-immolative thioester linked nucleic acids (TENA) is described. Oligo(thymine) (oT) TENA has a six-atom spacing between bases which allowed TENA to selectively base-pair with polyadenine R

Dynamic and Responsive DNA-like Polymers

The synthesis of thiolactone monomers that mimic natural nucleosides and engage in robust ring opening polymerizations (ROP) is herein described. As each repeat unit contains a thioester functional group, dynamic rearrangement of the polymer is feasible v

STABILISATION OF RADIOPHARMACEUTICAL PRECURSORS

The invention relates to a method for improving stability of radiopharmaceutical precursors, and in particular non radiolabelled nucleoside derivatives which are used as precursors for production of radiolabelled nucleoside derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The invention further includes formulations of radiopharmaceutical precursors, and cassettes for automated synthesis apparatus comprising the same.

Synthesis of 3′- and 5′-nitrooxy pyrimidine nucleoside nitrate esters: "Nitric oxide donor" agents for evaluation as anticancer and antiviral agents

A group of 3′-O-nitro-2′-deoxyuridines, 3′-O -nitro-2′-deoxycytidines and 5′-O-nitro-2′-deoxyuridines possessing a variety of substituents (H, Me, F, I) at the C-5 position were synthesized for evaluation as anticancer/antiviral agents that have the abili

Efficient transformation of thymidine into 2',3'-didehydro-2',3'-dideoxy- thymidine (D4T) involving opening of a 2,3'-anhydro derivative by phenylselenol

A new, high-yielding method for introduction of the selenophenyl residue at the 3'- position of thymidine is reported. This reaction avoided any strongly basic or reductive reagent, thus allowing the use of benzoate ester as a protective group at O-5'. Further oxidation-elimination sequence followed by basic deprotection afforded 2',3'-didehydro-2',3'- dideoxythymidine (D4T) in 67.5% overall yield from thymidine.

A New Synthesis f the Anti-AIDS Drug AZT from 5-Methyluridine

The anti-AIDS drug AZT is prepared in six steps in 44percent overall yield starting from the readily available ribonucleoside 5-methyluridine.