170874-96-1

Basic information

• Product Name: 4-oxo-4-phenyl-2-(thiophen-2-yl)butanenitrile
• Synonyms: 4-oxo-4-phenyl-2-(thiophen-2-yl)butanenitrile
• CAS NO: 170874-96-1
• Molecular Weight: 241.313
• Mol File: 170874-96-1.mol

Chemical Properties

• CAS DataBase Reference: 4-oxo-4-phenyl-2-(thiophen-2-yl)butanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-4-phenyl-2-(thiophen-2-yl)butanenitrile(170874-96-1)
• EPA Substance Registry System: 4-oxo-4-phenyl-2-(thiophen-2-yl)butanenitrile(170874-96-1)

Safety Data

• Hazardous Substances Data: 170874-96-1(Hazardous Substances Data)

Upstream product

• 89380-68-7 2-hydroxy-2-(thiophen-2-yl)acetonitrile 
• 98-86-2 acetophenone 
• 98-03-3 thiophene-2-carbaldehyde 
• 20102-12-9 2-hydroxy-2-phenylpropionitrile 
• 2910-81-8 3-(2'-thienyl)acrylophenone 
• 109-77-3 malononitrile 
• 151-50-8 potassium cyanide 

Relevant articles and documents

Cyano-borrowing reaction: Nickel-catalyzed direct conversion of cyanohydrins and aldehydes/ketones to β-cyano ketone

A direct nickel-catalyzed, high atom- and step-economical reaction of cyanohydrins with aldehydes or ketones via an unprecedented "cyano-borrowing reaction" has been developed. Cleavage of the C-CN bond of cyanohydrins followed by aldol condensation and conjugate addition of cyanide to α,β-unsaturated ketones proceeded to deliver a range of racemic β-cyano ketones with good to high yields. The practical procedure with the use of a commercial and less-toxic CN source bodes well for wide application of this protocol.

Cyanation of α,β-unsaturated enones by malononitrile in open air under metal-catalyst-free conditions

Cyanation of α,β-unsaturated enones by employing malononitrile as the organic cyanation source has been disclosed, which proceeds efficiently at room temperature in open air under metal-catalyst-free conditions. The Royal Society of Chemistry 2012.

PREPARATION AND REACTIONS OF SOME 2-THIENYL AND 3-THIENYL PYRIDAZINONES AND PYRIDAZINES

The preparation and reactions of some pyridazinone derivatives with 2- and 3-thienyl substituents are described.Precursor 4-oxobutanoic acids Ar2COCH2CH(Ar1)CO2H (Ar1=Pb, Ar2=2-thienyl and Ar1=2-thienyl, Ar2=Pb) were obtained by addition of HCN to the chalcones Ar1CH=CHCOAr2 followed by acid hydrolysis of the resulting nitrile.Nitriles, ArCOCH(CH3)CH2CN were prepared by the Michael-Stetter reaction and converted via the acids to the 4,5-dihydropyridazin-3(2H)-ones.Two methods wereused to obtain pyridazin-3(2H)-ones viz oxidation of the 4,5-dihydro derivatives with selenium dioxide and base-catalyzed condensation of methanal or aryl aldehydes at the 4-position of the 4,5-dihydro compound.