170884-76-1Relevant academic research and scientific papers
N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides. A New Class of Potent and Selective Ligands at the Peripheral Renzodiazepine Receptor
Primofiore, Giampaolo,Da Settimo, Federico,Taliani, Sabrina,Simorini, Francesca,Patrizi, Maria Paola,Novellino, Ettore,Greco, Giovanni,Abignente, Enrico,Costa, Barbara,Chelli, Beatrice,Martini, Claudia
, p. 1852 - 1855 (2007/10/03)
We report the synthesis and the affinity data at both the peripheral (PBR) and the central benzodiazepine receptors of a series of N,N-dialkyl-2-phenylindol-3-ylglyoxylamide derivatives III, designed as conformationally constrained analogues of 2-phenylin
Synthesis and antiserotonin activity of ethyl 5-O-(4-methylpiperazin-1-ylacetyl)-2-methylindole-3-carboxylates and 3-(4-methyl-1-piperazinylglyoxyl)indoles
Purohit, M. G.,Badiger, G. R.,Kalaskar, N. J.
, p. 796 - 801 (2007/10/03)
Ethyl-5-O-chloroacetyl-2-methylindole-3-carboxylates (2a-e) have been synthesised by the reaction of ethyl 5-hydroxy-2-methylindole-3-carboxylates (1a-e) with chloroacetyl chloride in dry benzene containing triethylamine.These indoles (2a-e) on condensation with methylpiperazine in dry acetone in the presence of anhydrous K2CO3, afford ethyl 5-O-(4-methylpiperazin-1-ylacetyl)-2-methylindole-3-carboxylates (3a-e).Compounds 3a-e are converted into their oxalate derivatives (4a-e).Indole-3-glyoxyl chlorides (6a-e) have been prepared from appropriate indoles (5a-e) byreaction with oxalyl chloride in dry ether. these derivatives on condensation with methylpiperazine yield 3-(4-methyl-1-piperazinylglyoxylyl)indoles (7a-e) wich are converted into oxalate salts (8a-e).Compounds 4a-e and 8a-e have been screened for their antiserotonin activity.Only compound 4d is found to exhibit antiserotonin activity.
