1709-39-3

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-N,N-DIETHYL-BENZENESULFONAMIDE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs, particularly in the fields of antibiotics and diuretics.
Used in Organic Synthesis:
In the field of organic synthesis, 4-AMINO-N,N-DIETHYL-BENZENESULFONAMIDE is utilized as a building block or a reagent in the creation of various organic compounds, taking advantage of its unique chemical structure and properties.

InChI:InChI=1/C10H16N2O2S/c1-3-12(4-2)15(13,14)10-7-5-9(11)6-8-10/h5-8H,3-4,11H2,1-2H3

Upstream product

• 2080-32-2 N⁴-acetyl-N¹-diethylsulfanilamide 
• 107145-69-7 N-dichlorophosphoryl-sulfanilyl chloride 
• 109-89-7 diethylamine 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 10026-13-8 phosphorus pentachloride 
• 121-57-3 4-aminobenzene sulfonic acid 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 89840-82-4 N,N-Diethyl-4-nitro-benzenesulfonamide 

Downstream Products

• 315672-03-8 N-(N-acetyl-sulfanilyl)-sulfanilic acid diethylamide 
• 94243-30-8 4-(Cyanomethyl-amino)-N,N-diethyl-benzenesulfonamide 
• 42556-43-4 4-((E)-3,7-Dimethyl-octa-2,6-dienylamino)-N,N-diethyl-benzenesulfonamide 
• 404862-98-2 5-amino-3-(4-N,N-diethylaminosulphonephenylamino)-1-phenylpyrazole-4-carboxamide 
• 96734-47-3 1-(4-Diethylsulfamoyl-phenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylic acid 
• 96722-84-8 1-(4-Diethylsulfamoyl-phenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylic acid diethyl ester 
• 94243-36-4 C₁₂H₁₆N₄O₃S 
• 88328-03-4 C₁₂H₁₇N₃O₅S 

Relevant academic research and scientific papers

Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators

NAD+ is a crucial cellular factor that plays multifaceted roles in wide ranging biological processes. Low levels of NAD+ have been linked to numerous diseases including metabolic disorders, cardiovascular disease, neurodegeneration,

Mesoionic Carbene-Iridium Complex Catalyzed Ortho-Selective Hydrogen Isotope Exchange of Anilines with High Functional Group Tolerance

Mesoionic carbene-iridium complex 1a has been investigated in the hydrogen isotope exchange (HIE) reaction of anilines. By employing 1 mol % of 1a as catalyst, anilines were selectively deuterated at the ortho-position with high deuteration levels. High ortho-selectivity was observed for anilines with various competing directing groups, which is in contrast with catalytic results of Kerr's catalysts.

Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors

We report on the discovery of norbornyl moiety as a novel structural motif for cyclin-dependent kinase 2 (CDK2) inhibitors which was identified by screening a carbocyclic nucleoside analogue library. Three micromolar hits were expanded by the use of medic

A simple synthesis of anilines by LiAlH4/TiCl4 reduction of aromatic nitro compounds

A rapid and efficient single-step synthesis of substituted anilines has been developed. The aromatic nitro compounds were reduced by using reducing systems generated by the action of an excess of LiAlH4 on TiCl4. Anilines substituted with different functional groups were synthesized in high yields and purity starting from the corresponding nitro compounds. The developed procedure is applicable to nitroaromatics containing both electron withdrawing and electron donating substituents. Substrates with electron donor substituents require a larger excess of LiAlH4. The reducing power of the prepared reactant systems depends on the used molar ratio of LiAlH4 and TiCl4.

A selective, tin-free radical mediated synthesis of indoles based on a sulfonate template

A synthesis of indoles based on a vinyl sulfonate template is described. The approach employs a sulfonate group which plays three discrete roles in the synthetic sequence. Firstly the highly electron-withdrawing sulfonate group behaves as an activating group for a 1,4-addition of an aniline to the unsaturated system. Secondly, the electron-withdrawing nature of the same group also allows it to behave as a radical stabilising group which facilitates radical cyclisation to an aromatic ring to yield a transient indoline. Finally, the pendant sulfonate group behaves as a leaving group to yield the indole.

TRIAZOLE COMPOUNDS AS LIPOXYGENASE INHIBITORS

There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15- lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

Neuropeptide Y antagonists

The compound is a neuropeptide Y antagonist and is effective in treating feeding disorders, cardiovascular diseases and other physiological disorders.

Amide derivatives useful as Neuropeptide Y (NPY) antagonists

The compound is a neuropeptide Y antagonist and is effective in treating feeding disorders, cardiovascular diseases and other physiological disorders.

Azo coupling of o- and p-(dialkylaminosulfonyl)benzene-diazonium salts with 7-acetylamino-4-hydroxynaphthalene-2-sulfonic acid in citrate-phosphate buffer solution

Dependences of the partial rate constants for azo coupling of o-(dialkylaminosulfonyl)benzene-diazonium salts with 7-acetylamino-4-hydroxynaphthalene-2-sulfonic acid (N-Acetyl-I-acid) on the fraction of the dianionic form of the latter indicate considerable steric hindrances to the second stage of the reaction. Ionization of the hydroxy group of N-acetyl-I-acid gives rise to additional electrostatic repulsion at the stage of formation of the σ complex, which reduces the rate of azo coupling at the 3-position of orthanilic acid.

4-Sulfonamidoanilide tertiary carbinols: A novel series of potassium channel openers

Sulfonamides are viable replacements for the phenylsulfonyl and benzoyl moieties initially described for the anilide tertiary carbinol series of K(ATP) potassium channel openers. The SAR of this new series and the synthetic chemistry employed to generate its members are described.