89840-82-4

Usage

Uses

Used in Organic Synthesis:
N,N-Diethyl-4-nitrobenzenesulfonamide is used as a building block for the synthesis of various organic compounds due to its reactivity and functional group compatibility.
Used in Drug Development:
N,N-Diethyl-4-nitrobenzenesulfonaMide is utilized as a reagent in drug development, leveraging its nitro-group properties to create pharmaceutically relevant molecules.
Used as a Dye Intermediate:
N,N-Diethyl-4-nitrobenzenesulfonamide is employed as an intermediate in the production of dyes, capitalizing on its chemical structure to contribute to the color and properties of the final dye products.
Used in Chemical Research:
In the field of chemical research, N,N-Diethyl-4-nitrobenzenesulfonaMide is used for studying the reactions and properties of nitroaromatics and sulfonamides, furthering the understanding of their behavior in different chemical contexts.
Safety Precautions:
It is crucial to handle N,N-Diethyl-4-nitrobenzenesulfonamide with care due to its potential hazardous properties. Appropriate safety measures should be implemented during its synthesis, storage, and use to ensure the well-being of individuals and the environment.

Upstream product

• 109-89-7 diethylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 155164-61-7 2-(4-nitrobenzenesulfonyl)-4,5-dichloropyridazin-3-one 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 121-44-8 triethylamine 

Downstream Products

• 96308-25-7 4-(2,2,2-trifluoroethoxy)-N,N-diethylbenzenesulfonamide 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 1709-39-3 4-(N,N-diethylaminosulfonyl)aniline 
• 1094225-40-7 N,N-diethyl-4-methylaminobenzenesulfonamide 
• 1352622-00-4 1-bromo-2-[(4-diethylsulfamoylphenyl)methylamino]ethanesulfonic acid 2,4,6-trichlorophenyl ester 
• 383388-43-0 N,N-diethyl-1-methyl-1H-indole-5-sulfonamide 
• 1352622-17-3 C₁₉H₂₃Cl₃N₂O₅S₂ 
• 315670-76-9 N-(4-(N,N-diethylsulfamoyl)phenyl)benzamide 

Relevant academic research and scientific papers

Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators

NAD+ is a crucial cellular factor that plays multifaceted roles in wide ranging biological processes. Low levels of NAD+ have been linked to numerous diseases including metabolic disorders, cardiovascular disease, neurodegeneration,

Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors

We report on the discovery of norbornyl moiety as a novel structural motif for cyclin-dependent kinase 2 (CDK2) inhibitors which was identified by screening a carbocyclic nucleoside analogue library. Three micromolar hits were expanded by the use of medic

Eosin Y-Sensitized Photocatalytic Reaction of Tertiary Aliphatic Amines with Arenesulfonyl Chlorides under Visible-Light Irradiation

A mild, practical, and environmentally friendly route to vinyl sulfones and sulfonamides has been developed based on the reaction of aliphatic amines with arenesulfonyl chlorides in the presence of eosin Y as a photocatalyst under visible light. The method permits the selective formation of vinyl sulfones or sulfonamides, depending on the oxidation environment and solvent. A wide range of products were obtained in moderate to good yields under the optimized conditions.

A selective, tin-free radical mediated synthesis of indoles based on a sulfonate template

A synthesis of indoles based on a vinyl sulfonate template is described. The approach employs a sulfonate group which plays three discrete roles in the synthetic sequence. Firstly the highly electron-withdrawing sulfonate group behaves as an activating group for a 1,4-addition of an aniline to the unsaturated system. Secondly, the electron-withdrawing nature of the same group also allows it to behave as a radical stabilising group which facilitates radical cyclisation to an aromatic ring to yield a transient indoline. Finally, the pendant sulfonate group behaves as a leaving group to yield the indole.

Oxidation of aromatic and aliphatic triisopropylsilanylsulfanyls to sulfonyl chlorides: Preparation of sulfonamides

A series of aromatic and aliphatic triisopropylsilanylsulfanyls were prepared and oxidized to the sulfonyl chlorides with KNO3/SO 2Cl2. The sulfonyl chlorides were characterized via their conversion to sulfonamides.

Arenesulfonylheterocycles (I): Synthesis and reactions of 2-benzenesulfonyl-4,5-dichloropyridazin-3-ones with amines

The direct sulfonylation of 4,5-dichloropyridazin-3-ones with some benzenesulfonyl chlorides in the presence of base in tetrahydrofuran gave only the corresponding N-sulfonylated product. The reaction of 2-benzenesulfonyl-4,5-dichloropyridazin-3-ones with some aliphatic amines under neutral conditions afforded 5-alkylamino-2-benzenesulfonyl-4-chloropyridazin-3-ones and/or the corresponding N-alkyl-benzenesulfonamides.

Neuropeptide Y antagonists

The compound is a neuropeptide Y antagonist and is effective in treating feeding disorders, cardiovascular diseases and other physiological disorders.

Amide derivatives useful as Neuropeptide Y (NPY) antagonists

The compound is a neuropeptide Y antagonist and is effective in treating feeding disorders, cardiovascular diseases and other physiological disorders.