17090-18-5Relevant academic research and scientific papers
Copper-mediated regioselective efficient direct ortho-nitration of anilide derivatives
Reddy Depa, Manmohan,Potla, Suneetha,Narkhede, Umesh C.,Jadhav, Vinod D.,Vidavalur, Siddaiah
, (2020)
The mild and readily available Cu(NO3)2 mediated ortho nitration of anilides with broad substrate using K2S2O8 as an oxidant in the absence of any other metal catalyst and nitrating agent under mild conditions was reported for the first time.
Polysubstituted tryptamine benzamide compound and preparation method and application thereof
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Paragraph 0034; 0044; 0049, (2020/05/30)
The invention discloses a polysubstituted tryptamine benzamide compound and a preparation method and application thereof. The compound is characterized in that the compound is a polysubstituted tryptamine benzamide compound with a structural formula shown as a formula I or a pharmaceutically acceptable salt, ester or solvate of the polysubstituted tryptamine benzamide compound with the structuralformula shown as the formula I. The preparation method comprises the following steps: (1) carrying out amide synthesis reaction on a compound shown in a formula II and a compound shown in a formula III to obtain a compound shown in a formula IV; and (2) reacting the compound as shown in the formula IV with V to carry out Michael addition reaction so as to obtain a compound as shown in the formulaI. The polysubstituted tryptamine benzamide compound and a preparation method and application thereof have the advantages that tumor growth can be effectively inhibited, so that growth stagnation, differentiation or apoptosis of tumor cells is induced, and the effect of inhibiting tumor cell proliferation is achieved.
SMALL MOLECULE INHIBITORS OF SRC TYROSINE KINASE
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Page/Page column 71-72, (2021/01/22)
Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof. Also disclosed herein are methods of using the compounds of Formula (I) in the treatment of certain diseases (e.g., cancer).
Copper-Catalyzed Direct Nitration on Aryl C-H Bonds by Concomitant Azidation-Oxidation with TMS Azide and TBHP under Aerobic Conditions
Vinayak, Botla,Chandrasekharam, Malapaka
supporting information, p. 3528 - 3531 (2017/07/17)
An unprecedented copper-catalyzed in situ azidation-oxidation for the nitration of anilides and sulfonamides has been developed by direct CAr-H functionalization. This novel and efficient nitration protocol is achieved employing TMSN3 and TBHP without the exclusion of air or moisture. The synthetic applications of the 2-nitroanilides have been explored.
