170911-99-6

Upstream product

• 111373-03-6 2-(piperazin-1-yl)benzonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 53157-48-5 tert-butyl 2-(5-hydroxy-1H-indol-3-yl)ethylcarbamate 
• 177488-98-1 2-(4-(2-chloroacetyl)piperazin-1-yl)benzonitrile 

Downstream Products

• 170912-00-2 [2-(5-{2-[4-(2-Aminomethyl-phenyl)-piperazin-1-yl]-2-oxo-ethoxy}-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester 
• 1027908-00-4 {2-[5-(2-{4-[2-(Methanesulfonylamino-methyl)-phenyl]-piperazin-1-yl}-2-oxo-ethoxy)-1H-indol-3-yl]-ethyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

INDOLE-DERIVED ARYLPIPERAZINES AS LIGANDS FOR 5HT1-LIKE, 5HT1B AND 5HT1D RECEPTORS

Novel indole-derived azylpiperazines of general formula (I), wherein, inter alia, R 1 is NH 2 or NO 2, R' 1, R 2, R' 2, R 3 and R 4 are H, Z is--C--and X is 0. Methods for preparing such derivatives and the therapeutical uses thereof are also disclosed.

Synthesis and serotonergic activity of arylpiperazide derivatives of serotonin: Potent agonists for 5-HT(1D) receptors

A series of new arylpiperazide derivatives of serotonin has been prepared and evaluated as 5-HT(1D) receptor agonists. Binding experiments at cloned human 5-HT(1Dα), 5-HT(1Dβ), and 5-HT(1A) receptors show that all the compounds are very potent and selecti