170948-55-7

Upstream product

• 160461-82-5 8,10-dichloropyrido<3,2-f>quinoxaline 
• 69019-09-6 4-hydroxy-3-piperidinomethylaniline 
• 170948-54-6 10-chloropyrido<3,2-f>quinoxaline-7-oxide 
• 170948-61-5 10-chloropyrido<3,2-f>quinoxaline 
• 70039-09-7 2-(quinoxalin-6-ylaminomethylene)malonic acid diethyl ester 
• 70039-10-0 10-oxo-7,10-dihydro-pyrido[3,2-f]quinoxaline-9-carboxylic acid ethyl ester 
• 70039-11-1 10-oxo-7,10-dihydro-pyrido[3,2-f]quinoxaline-9-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and antimalarial activity of pyridoquinoxalines and their N-oxides

Unsubstituted, 2,3-dimethyl, and 2,3-diphenyl 10-chloro pyridoquinoxalines have been prepared and converted to 10-substituted amino and Mannich base derivatives.Pyridoquinoxaline undergoes oxidation in the presence of m-CPBA to give the corresponding mono and bis N-oxides.The mono N-oxide reacts with POCl3 to give the dichloro derivative and with trimethyl silyl cyanide to give the 8-cyano-10-chloro derivative.The dichloro pyridoquinoxaline further undergoes oxidation with m-CPBA to give dichloro mono N-oxide.All the compounds have beeen testedin the Plasmodium berghei infected mice by oral route.Compounds 9, and 12 displayed 100percent activity in K-173 infected mice at 25 mg/kg.