69019-09-6

Upstream product

• 77802-91-6 4-nitro-2-(piperidin-1'-ylmethyl)phenol 
• 110-89-4 piperidine 
• 103-90-2 4-acetaminophenol 
• 13886-01-6 N-(4-Hydroxy-3-piperidinomethylphenyl)acetamid 

Downstream Products

• 136809-72-8 4-benzylidene-1-(4-hydroxy-3-piperidinomethylphenyl)-2-methylimidazolidin-5-one 
• 107400-00-0 Benzofuran-2-carboxylic acid (4-hydroxy-3-piperidin-1-ylmethyl-phenyl)-amide 
• 107399-88-2 4-Oxo-3,4-dihydro-quinazoline-2-carboxylic acid (4-hydroxy-3-piperidin-1-ylmethyl-phenyl)-amide 
• 93958-36-2 N-(4-isothiocyanatophenyl)-N'-<4-hydroxy-3-(piperidin-1-yl)methyl>phenlthiourea 
• 93958-38-4 N-(4-nitrophenyl)-N'-<4-hydroxy-3-(piperidin-1-yl)methyl>phenlthiourea 
• 170948-55-7 8-chloro-10-(4-hydroxy-3-piperidinomethyl)anilinopyrido<3,2-f>quinoxaline 
• 121814-31-1 5-trans-cinnamoylamino-2-trans-cinnamoyloxy-α-piperidino-toluene 
• 123966-17-6 4-(4-methoxy-benzoylamino)-1-(4-methoxy-benzoyloxy)-2-piperidinomethyl-benzene 
• 123966-12-1 2-piperidinomethyl-4-p-toluoylamino-1-p-toluoyloxy-benzene 

Relevant academic research and scientific papers

Aromatic amino analogues of artemisinin: Synthesis and in vivo antimalarial activity

Nine orally active novel artemisinin derivatives were prepared from artemisinin by four-step synthesis, and the compounds were evaluated in the rodent model using multidrug resistant Plasmodium yoelii nigeriensis. All of the compounds exhibited antimalarial activities with the ED50 ranging from 5.41 mg/kg-12.4 mg/kg. Among them, artemisinin derivative bearing N-(4-hydroxy-3- ((4-phenylpiperazin-1-yl)methyl)phenyl) moiety (5f) was found to be the most active compound and was found to be three times more potent than artemisinin (ED50 16.4 mg/kg). Birkhaeuser Boston 2009.

Microwave-induced Mannich reaction - Synthesis of some Mannich derivatives of p-aminophenol

Mono and bis substituted dialkylamino alkyl-p-aminophenol 3 are prepared by treating paracetamol 1 with formaldehyde and appropriate secondary amines followed by deacetylation using 6 M HCI in unmodified domestic microwave oven in unsealed borosil vessels

Synthesis of new arylaminoquinoxalines and their antimalarial activity in mice

2-Arylaminoquinoxalines were prepared by the condensation of 2-chloroquinoxaline with the appropriate Mannich bases in the presence of HCI. To synthesize the Mannich bases, 4-acetamidophenol was reacted with formaldehyde and dialkylamine to yield 3-[(dial

Potential Antimalarials. XVII. Di- and Mono-Mannich Bases of 2(and 4)-phenol

Di- and mono-Mannich base derivatives of 2(and 4)-phenols have been prepared for comparison with the 7-trifluoromethyl isomers in tests for antimalarial activity.The order of activity in in vitro tests against t