170968-81-7Relevant academic research and scientific papers
Chiral pyridylsulfonyl ester compound, and preparation method and application thereof
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Paragraph 0114-0120, (2019/10/01)
The invention discloses a chiral pyridylsulfonyl ester compound, and a preparation method thereof. The compound is used as a Lewis base to activate trichlorosilane, and the activation of the trichlorosilane can realize the selective catalytic reduction of
Method for preparing optically active alpha-hydroxy-beta-amino acid compounds
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Paragraph 0083-0105, (2019/10/01)
The invention discloses a method for preparing optically active N-acyl-beta-hydroxy-amino ester compounds of formula II from alpha-acyloxy-beta-enamine ester compounds through a one-pot process. The method uses novel six-membered cyclic pyridinecarboxamid
Synthesis of chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound method (by machine translation)
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Paragraph 0049-0050, (2017/02/24)
The present invention discloses a synthetic chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound method, its synthesis steps are as follows: to nitryl animal pen and acetaldehyde acid ester compound as the raw material, under the catalysis of chiral organic base, the reaction in an organic solvent, first preparation of chiral 3-nitro-3-phenyl-2-hydroxy carboxylic acid ester compound, then passes through the reduction acidylated preparation of chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound; this invention relates to method of cheap and easily obtained raw material, preparation of chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound less steps, the final yield is high; this invention is mainly applied to medicine intermediate chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound synthesis. (by machine translation)
Chemo- and biocatalytic strategies to obtain phenylisoserine, a lateral chain of Taxol by asymmetric reduction
Rimoldi, Isabella,Pellizzoni, Michela,Facchetti, Giorgio,Molinari, Francesco,Zerla, Daniele,Gandolfi, Raffaella
experimental part, p. 2110 - 2116 (2012/03/27)
Enriched ethyl 3-benzamido-2-hydroxy-3-phenylpropanoate (protected phenylisoserine), the chiral side chain of Taxol, was obtained via asymmetric reduction with transition metal-diphoshine complexes or with whole cells of non-conventional yeasts. Asymmetri
