39090-78-3Relevant academic research and scientific papers
An unusual contra-Michael addition of NaNO2-ceric ammonium nitrate to acrylic esters
Buevich, Alexei V.,Wu, Yusheng,Chan, Tze-Ming,Stamford, Andrew
, p. 2132 - 2135 (2008)
This report describes a novel regioselective contra-Michael addition to cinnamic esters that utilizes NaNO2-ceric ammonium nitrate.
Synthesis of chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound method (by machine translation)
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Paragraph 0027-0028, (2017/02/24)
The present invention discloses a synthetic chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound method, its synthesis steps are as follows: to nitryl animal pen and acetaldehyde acid ester compound as the raw material, under the catalysis of chiral organic base, the reaction in an organic solvent, first preparation of chiral 3-nitro-3-phenyl-2-hydroxy carboxylic acid ester compound, then passes through the reduction acidylated preparation of chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound; this invention relates to method of cheap and easily obtained raw material, preparation of chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound less steps, the final yield is high; this invention is mainly applied to medicine intermediate chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound synthesis. (by machine translation)
Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1
Kher, Samir S.,Penzo, Maria,Fulle, Simone,Finn, Paul W.,Blackman, Michael J.,Jirgensons, Aigars
supporting information, p. 4486 - 4489 (2015/02/19)
Peptidic α-ketoamides have been developed as inhibitors of the malarial protease PfSUB1. The design of inhibitors was based on the best known endogenous PfSUB1 substrate sequence, leading to compounds with low micromolar to submicromolar inhibitory activity. SAR studies were performed indicating the requirement of an aspartate mimicking the P1′ substituent and optimal P1-P4length of the non-prime part. The importance of each of the P1-P4amino acid side chains was investigated, revealing crucial interactions and size limitations.
Nitroalkanes and ethyl glyoxalate as common precursors for the preparation of both β-keto esters and α,β-unsaturated esters
Ballini, Roberto,Fiorini, Dennis,Palmieri, Alessandro
, p. 7027 - 7029 (2007/10/03)
β-Nitro acrylic esters, obtained by the reaction of nitroalkanes and ethyl glyoxalate, are the key building blocks for the immediate synthesis of both the title compounds. In fact, their treatment with titanium trichloride produce the direct conversion to the β-keto esters, while their reaction with sodium boron hydride gives the one-pot synthesis of α,β- unsaturated esters through formal substitution of the vinylic nitro group with an hydrogen.
