1709825-83-1

Basic information

• Product Name: beclomethasone-11,17,21-tripropionate
• CAS NO: 1709825-83-1
• Molecular Weight: 577.115
• Mol File: 1709825-83-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 645.9±55.0 °C(Predicted)
• Density: 1.24±0.1 g/cm3(Predicted)
• CAS DataBase Reference: beclomethasone-11,17,21-tripropionate(CAS DataBase Reference)
• NIST Chemistry Reference: beclomethasone-11,17,21-tripropionate(1709825-83-1)
• EPA Substance Registry System: beclomethasone-11,17,21-tripropionate(1709825-83-1)

Safety Data

• Hazardous Substances Data: 1709825-83-1(Hazardous Substances Data)

Usage

General Description

Beclomethasone-17,21-dipropionate is a synthetic glucocorticoid steroid that is used as an anti-inflammatory and immunosuppressive agent. It is primarily used to treat inflammatory conditions such as asthma, allergic rhinitis, and chronic obstructive pulmonary disease. Beclomethasone-17,21-dipropionate works by reducing inflammation and swelling in the airways, making it easier to breathe. It is usually administered via inhalation, but can also be found in topical creams and ointments for skin conditions. Beclomethasone-17,21-dipropionate is generally well-tolerated, but may cause side effects such as throat irritation, coughing, and hoarseness. It is important to use this medication as directed by a healthcare professional to minimize the risk of side effects.

Upstream product

• 981-34-0 9β,11β-epoxy-17α,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 
• 4419-39-0 beclomethasone 
• 123-62-6 propionic acid anhydride 
• 79-03-8 propionyl chloride 

Relevant articles and documents

Practical and scalable synthesis of beclomethasone dipropionate

Beclomethasone dipropionate (1) is a synthetic corticosteroid with anti-inflammatory, antipruritic, and anti-allergy properties. It is widely used to treat asthma, allergic rhinitis, and dermatoses. However, existing synthetic routes to this active pharmaceutical ingredient (API) contain steps resulting in low and/or inconsistent yields, and use obsolete reagents. Such inconsistencies coupled with a lack of reliable experimental data makes laboratory-scale and large-scale synthesis of this API difficult and time-consuming. In this paper, we report a practical and scalable approach to synthesize 1 from the readily available steroidal intermediate, 16β-methyl epoxide (3, DB-11). A gram-scale to kilogram-scale synthesis of 1 was achieved with 82% yield, using a cost-effective and scalable methodology. Selective propionylation of the hydroxyl groups at C17 and C21 demonstrate the fact that this approach can be conveniently implemented in fine chemical industries.

A dipropionate double-c ester synthesis method free of organic solvents

The invention relates to a synthetic method of a beclomethasone dipropionate organic-free solvent. According to the method, beclomethasone 11, 17, 21-tripropionate is taken as the raw material and reacts in an organic solvent with a gluconic acid solution or an aqueous solution of ester capable of being converted into gluconic acid in water to prepare the beclomethasone dipropionate organic-free solvent.