17104-81-3Relevant academic research and scientific papers
Tripod with two handles shape tetramine pi and preparation method, tripod with two handles shape tetramine pi film modified electrode and its preparation method (by machine translation)
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Paragraph 0090; 0094, (2018/03/26)
The invention relates to a tripod with two handles shape tetramine pi and preparation method, tripod with two handles shape tetramine pi film modified electrode and its preparation method, which belongs to the electrode surface modification material technical field, in the prior art of interface modifying method adopts the bridged the molecular system synthesis difficult, poor stability and surface adsorption efficiency is low. The tripod with two handles shape tetramine pi, has the following structure, the 1, 3, 6, 8 - four bromines pi two fragrant amines derivatives with catalytic palladium catalyst under the coupling reaction. The invention provides a tripod with two handles shape tetramine pi can be used for modifying the electrode. (by machine translation)
Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N -phenyl-aminobenzoates and their structure-activity relationships
Adeniji, Adegoke O.,Twenter, Barry M.,Byrns, Michael C.,Jin, Yi,Chen, Mo,Winkler, Jeffrey D.,Penning, Trevor M.
supporting information; experimental part, p. 2311 - 2323 (2012/05/04)
Aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) is overexpressed in castration resistant prostate cancer (CRPC) and is implicated in the intratumoral biosynthesis of testosterone and 5α-dihydrotestosterone. Selective AKR1C3 inhibitors are required because compounds should not inhibit the highly related AKR1C1 and AKR1C2 isoforms which are involved in the inactivation of 5α-dihydrotestosterone. NSAIDs, N-phenylanthranilates in particular, are potent but nonselective AKR1C3 inhibitors. Using flufenamic acid, 2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid, as lead compound, five classes of structural analogues were synthesized and evaluated for AKR1C3 inhibitory potency and selectivity. Structure-activity relationship (SAR) studies revealed that a meta-carboxylic acid group relative to the amine conferred pronounced AKR1C3 selectivity without loss of potency, while electron withdrawing groups on the phenylamino B-ring were optimal for AKR1C3 inhibition. Lead compounds did not inhibit COX-1 or COX-2 but blocked the AKR1C3 mediated production of testosterone in LNCaP-AKR1C3 cells. These compounds offer promising leads toward new therapeutics for CRPC.
Cathodic reduction of diazonium salts in aprotic medium
Barba, Fructuoso,Batanero, Belen,Tissaoui, Khalil,Raouafi, Noureddine,Boujlel, Khaled
experimental part, p. 973 - 976 (2011/11/05)
Cathodic reduction of diazonium salts in acetonitrile led to the formation of azobenzenes, in good to moderate yields, and diarylamines as minoritary products. The reactions were carried out at the second reduction potential of the diazonium salts, involving aryl anions in the formation of the products.
The use of hydroxylamine hydrochloride in the Chan-Lam reaction: A simple access to symmetric diarylamines
Zhou, Changfeng,Yang, Dongpeng,Jia, Xiaofei,Zhang, Lixue,Cheng, Jiang
scheme or table, p. 3198 - 3200 (2010/03/31)
A CuBr-catalyzed coupling reaction of hydroxylamine hydrochloride and arylboronic acids is described, providing a simple and efficient methodology for the synthesis of symmetric diaryl amines. The reaction shows good functional group tolerance. Georg Thie
Non-Glycosidic and Non-Peptidic Select Inhibitors, and the Use Thereof
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, (2008/06/13)
A new class of non-glycosidic and non-peptidic inhibitors of selectins with low molecular weight according to the general formula 1 is described, as well as methods for their production. These compounds represent a new class of non-toxic, in vivo anti-inf
NON-GLYCOSIDIC AND NON-PEPTIDIC SELECT INHIBITORS, AND THE USE THEREOF
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Page/Page column 29, (2008/06/13)
The invention relates to a category of non-glycosidic and non-peptidic select inhibitors of general formula (1), with a low molecular weight, and to a method for the production thereof. Said category is a category of non-toxic select inhibitors having an
A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors
Ulbrich, Holger K.,Luxenburger, Andreas,Prech, Philip,Eriksson, Einar E.,Soehnlein, Oliver,Rotzius, Pierre,Lindbom, Lennart,Dannhardt, Gerd
, p. 5988 - 5999 (2007/10/03)
An early step of the inflammatory response, the rolling of leukocytes on activated endothelial cells, is mediated by selectin/carbohydrate interactions. The tetrasaccharide sialy LewisX is a ligand for E-, P-, and L-selectin and therefore serve
