171075-74-4Relevant academic research and scientific papers
Diverse synthesis of the C ring fragment of bryostatins via Zn/Cu-promoted conjugate addition of α-hydroxy iodide with enone
Chu, Zhiwen,Tong, Ruiqi,Yang, Yufan,Song, Xuanyi,Hu, Tian bao,Fan, Yu,Zhao, Chen,Gao, Lu,Song, Zhenlei
supporting information, p. 1 - 4 (2020/12/21)
A convergent approach to 1,5-hydroxy ketones, the general precursors for constructing the C ring of bryostatins, has been developed via a Zn/Cu-promoted conjugate addition of α-hydroxy iodides with enones. The reaction leads to direct formation of the C21-C22 bond and tolerates diverse functionalities at the C17-, C18- and C24-positions. The approach also enables a more concise synthesis of the known C ring intermediate (10 longest linear steps and 14 total steps), in contrast to its previous synthesis (17 longest linear steps and 22 total steps) in our total synthesis of bryostatin 8.
Bryostatins C-ring skeleton compound, synthesis method and application thereof
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Paragraph 0064, (2020/12/31)
The invention discloses a class of bryostatins C-ring skeleton compounds, a synthesis method and application thereof, and belongs to the technical field of chemical synthesis of natural products. According to the preparation method, a ketene compound and an iodohydrocarbon compound are subjected to a water-phase free radical coupling reaction to obtain a C-ring precursor compound, namely bryostatins C-ring skeleton compound, ring closing, epoxidation epoxy opening, oxidation and Aldol reaction are performed under acidic conditions to obtain a bryostatins C ring precursor known compound, and incombination with the prior art (such as Luch reduction butyrylation, TABF desilication, DMP oxidation, Sharpless asymmetric dihydroxylation reaction and the like), an analogue of the bryostatins C compound is obtained as an important synthon compound library for drug screening, so that the drug development and the clinical research of the Bryostatins family are promoted. According to the invention, the synthesis process is high in synthesis efficiency, and compared with an existing synthesis route, the operation steps are reduced, and the whole synthesis period is shortened.
Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds
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Paragraph 0178; 0179, (2014/08/19)
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, and the variables R1 and R2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
A convergent route to β-hydroxy δ-lactones through Prins cyclisation as the key step: Synthesis of (+)-prelactones B, C and V
Yadav,Reddy, M. Sridhar,Prasad
, p. 2133 - 2136 (2007/10/03)
Reactions of homoallylic alcohols with aldehydes in the presence of acid catalysts gave multisubstituted tetrahydropyrans with the creation of one to three new stereogenic centres in a single-pot process. The utility of this approach is extended to the en
A Concise Enantioselective Synthesis of (+)-Muscarine from (R)-O-Benzylglycidol
Takano, Seiichi,Iwabuchi, Yoshiharu,Ogasawara, Kunio
, p. 1371 - 1372 (2007/10/02)
A concise enantioselective synthesis of (+)-muscarine has been established via the novel formation of a 3,4-dihydrofuran starting from (R)-O-benzylglycidol.
