171079-93-9Relevant academic research and scientific papers
A chloroacetate based ratiometric fluorescent probe for cysteine detection in biosystems
Liu, Zhengkun,Wang, Qianqian,Wang, Hao,Su, Wenting,Dong, Shouliang
supporting information, (2019/10/08)
The specific detection of cysteine (Cys) over homocysteine (Hcy), glutathione (GSH) and other amino acids is of great significance for studying its biological functions as well as for the diagnosis of related diseases. Chloroacetyl group was often used as a reaction site for cysteine fluorescent probes for its sensitivity and selectivity. However, high background fluorescence and low stability are common problems encountered by such probes. Here, four chloroacetyl group based fluorescent probes (C1, C2, C3, and H4) was synthesized for a comparative study. We found that the inefficient quenching ability of chloroacetyl group turned into an advantage when connected with a ratiometric fluorophore. With the modification of chloroacetyl group, probe H4 displayed excellent ratiometric property and great selectivity for Cys, the stability was also improved. Additionally, the probe was successfully applied for quantitative detection of Cys in fetal bovine serum and real-time imaging in living HeLa cells with low toxicity.
The 2-(2-Chloroacetoxyethyl)benzoyl Group - Stable to Hydrogenolysis and Cleavable beside other Acyl Groups
Ziegler, Thomas,Pantkowski, Guido
, p. 5727 - 5730 (2007/10/02)
The 2-(2-chloroacetoxyethyl)benzoyl (CAEB) group is prepared from isochromane in 4 steps and used as a temporary protecting group for carbohydrates.The CAEB group functions as a neighboring active, 1,2-trans-directing blocking group for glycosyl donors.It
