42247-75-6Relevant articles and documents
A chloroacetate based ratiometric fluorescent probe for cysteine detection in biosystems
Liu, Zhengkun,Wang, Qianqian,Wang, Hao,Su, Wenting,Dong, Shouliang
supporting information, (2019/10/08)
The specific detection of cysteine (Cys) over homocysteine (Hcy), glutathione (GSH) and other amino acids is of great significance for studying its biological functions as well as for the diagnosis of related diseases. Chloroacetyl group was often used as a reaction site for cysteine fluorescent probes for its sensitivity and selectivity. However, high background fluorescence and low stability are common problems encountered by such probes. Here, four chloroacetyl group based fluorescent probes (C1, C2, C3, and H4) was synthesized for a comparative study. We found that the inefficient quenching ability of chloroacetyl group turned into an advantage when connected with a ratiometric fluorophore. With the modification of chloroacetyl group, probe H4 displayed excellent ratiometric property and great selectivity for Cys, the stability was also improved. Additionally, the probe was successfully applied for quantitative detection of Cys in fetal bovine serum and real-time imaging in living HeLa cells with low toxicity.
BENZOFURAN-2-SULFONAMIDES DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS
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, (2013/09/12)
The present invention relates to novel benzofuran-2-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
Functionalized esters as bis-electrophiles in a silicon-induced domino synthesis of annulated carbocycles
Genrich, Florian,Harms, Guido,Schaumann, Ernst,Gjikaj, Mimoza,Adiwidjaja, Gunadi
experimental part, p. 5577 - 5587 (2009/12/03)
The reaction of silyl-substituted carbanion 1b with arene-1,2-dicarboxylates 6, 15 yields indenone derivatives 11, 16 in a domino process involving silyl C→O migration and elimination. However, in a competing pathway, the initial addition of 1b leads to l
Stereoselective cascade reactions that incorporate a 7-exo acyl radical cyclization
Grant, Seth W.,Zhu, Koudi,Zhang, Yu,Castle, Steven L.
, p. 1867 - 1870 (2007/10/03)
Radical cascades that feature a 7-exo acyl radical cyclization followed by a 6-exo or 5-exo alkyl radical cyclization proceed with very good yields and diastereoselectivities. Two Stereocenters are created by the reaction, and a single isomeric product wa
Proximately Assisted and Chemoselectively Cleavable Protecting Groups for Alcohols, 2-benzoic Esters
Watanabe, Yutaka,Ishimaru, Masanori,Ozaki, Shoichiro
, p. 2163 - 2166 (2007/10/02)
Alcohols were protected by esterification with new protecting reagents, 2-benzoic acids and the esters were chemoselectively deprotected in a proximately assisted manner even in the presence of acetyl, levulinyl, and silyl groups.
Selective Photoinduced Oxidation of Benzylic Methylen Groups through UV Irradiation in Presence of Ferric Chloride
Barbier, Michel
, p. 866 - 869 (2007/10/02)
Selective oxidation of benzylic methylene groups through UV irradiation in acetone/water/FeCl3 mixtures is reported.This method applied to a series of model compounds, provides an easy access to the corresponding 1-oxo derivative.Thus, tetralin gives a 100percent yield of 1-tetralone, indane leads to 60percent of 1-indanone, and diphenylmethane is oxidized to benzophenone with 80percent yield.However, under the same conditions, alkyl-substituted aromatic hydrocarbons such as toluene, ethyl- and propylbenzene lead to low yields of aldehydes or ketones.Isochromane furnishes a mixture of two substances which can be interconverted, namely the expected 1-isochromanone (9percent) and the corresponding hydroxy acid (23percent).We failed to apply the method to nitrogen heterocycles containing benzylic groups such as 1,2,3,4- and 5,6,7,8-tetrahydroquinoline as they do not react due to the formation of complexes which precipitate from the solutions.
