171110-94-4Relevant articles and documents
Synthesis of diether-linked cationic lipids for gene delivery
Ren, Tan,Liu, Dexi
, p. 1247 - 1250 (2007/10/03)
Quaternary ammonium lipids 1b-d, with diether linkages between hydrocarbon chains and butane or hexane backbone, were synthesized for cationic liposome-mediated gene delivery. The synthetic strategy of using C- 4 or C-6 synthon permits the achievement of the variation of the hydrophobic domain as well as changes of space between the quaternary ammonium head and the hydrophobic domain in the diether-linked cationic lipids.
Preparation of optically active diol derivatives by the enzymatic hydrolysis of cyclic carbonates
Matsumoto, Kazutsugu,Fuwa, Seiji,Shimojo, Megumi,Kitajima, Hidehiko
, p. 2977 - 2987 (2007/10/03)
A simple enzymatic method for the preparation of optically active 1,2- and 1,3-diol derivatives is disclosed. In the screening of enzymes, racemic 4-[(2-benzyloxy)ethyl]-1,3-dioxolan-2-one (1a) was enantioselectively hydrolyzed by porcine pancreas lipase (PPL) to give optically active (R)-1a and (S)-4-(benzyloxy)butane-1,2-diol (2a). The addition of 10% i-PT2O to the reaction system dramatically improved the reactivity to afford optically pure (A)-1a in 31% yield. PPL also catalyzed the hydrolysis of several five-membered cyclic carbonates with high enatioselectivity. It is noteworthy that the increment of the carbon number of the substituents reflects the drastic increase in enantioselectivity. On the other hand, the hydrolyses of six- and seven-membered cyclic carbonates were also catalyzed by PPL. In particular, the reaction of a six-membered substrate enantioselectively proceeded. This reaction afforded optically active 1,3-diol derivatives which could not be directly prepared by hitherto known methods using hydrolytic enzymes.
Enzyme-mediated enantioselective hydrolysis of cyclic carbonates
Matsumoto, Kazutsugu,Fuwa, Seiji,Kitajima, Hidehiko
, p. 6499 - 6502 (2007/10/02)
The enzyme-mediated enantioselective hydrolysis of cyclic carbonates is disclosed. Racemic 4-(2-benzyloxy)ethyl-1,3-dioxolan-2-one (1a) was enantioselectively hydrolyzed by porcine pancreas lipase (PPL) to give optically active (R)-1a and (S)-4-benzyloxybutane-1,2-diol (2a). PPL also catalyzed the hydrolysis of several five-membered cyclic carbonates with high enantioselectivity.
