171110-94-4

Basic information

• Product Name: 1,3-Dioxolan-2-one, 4-[2-(phenylmethoxy)ethyl]-
• CAS NO: 171110-94-4
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Mol File: 171110-94-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolan-2-one, 4-[2-(phenylmethoxy)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolan-2-one, 4-[2-(phenylmethoxy)ethyl]-(171110-94-4)
• EPA Substance Registry System: 1,3-Dioxolan-2-one, 4-[2-(phenylmethoxy)ethyl]-(171110-94-4)

Safety Data

• Hazardous Substances Data: 171110-94-4(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 71998-69-1 (+/-)-4-benzyloxy-butane-1,2-diol 
• 105-58-8 Diethyl carbonate 
• 100-44-7 benzyl chloride 
• 94426-71-8 (+/-)-4-(2-benzyloxyethyl)-2,2-dimethyl-1,3-dioxolane 
• 100-39-0 benzyl bromide 
• 70388-33-9 4-benzyloxybut-1-ene 

Downstream Products

• 71998-69-1 (S)-4-benzyloxy-1,2-butanediol 
• 69985-32-6 (R)-4-phenylmethoxy-1,2-butanediol 
• 6414-28-4 4-(2-hydroxyethyl)-1,3-dioxolan-2-one 
• 233759-67-6 4-(2-trityloxy-ethyl)-[1,3]dioxolan-2-one 

Relevant articles and documents

Synthesis of diether-linked cationic lipids for gene delivery

Quaternary ammonium lipids 1b-d, with diether linkages between hydrocarbon chains and butane or hexane backbone, were synthesized for cationic liposome-mediated gene delivery. The synthetic strategy of using C- 4 or C-6 synthon permits the achievement of the variation of the hydrophobic domain as well as changes of space between the quaternary ammonium head and the hydrophobic domain in the diether-linked cationic lipids.

Enzyme-mediated enantioselective hydrolysis of cyclic carbonates

The enzyme-mediated enantioselective hydrolysis of cyclic carbonates is disclosed. Racemic 4-(2-benzyloxy)ethyl-1,3-dioxolan-2-one (1a) was enantioselectively hydrolyzed by porcine pancreas lipase (PPL) to give optically active (R)-1a and (S)-4-benzyloxybutane-1,2-diol (2a). PPL also catalyzed the hydrolysis of several five-membered cyclic carbonates with high enantioselectivity.