94426-71-8Relevant academic research and scientific papers
Condensation of 1,2,4-Butanetriol with Carbonyl Compounds and Reactions of Hydroxyalkyl-1,3-dioxacyclanes
Raskil’dina,Borisova, Yu. G.,Zlotskii
, p. 1601 - 1605 (2018/11/10)
A mixture of isomers of 2-(1,3-dioxolan-4-yl)ethanol and 1,3-dioxan-4-ylmethanol was prepared by reaction of 1,2,4-butanetriol with paraformaldehyde. This mixture was subjected to O-alkylation, O-acylation, condensation with phenyl isocyanate, and substitution of OH groups for Cl. The relative activity of acetone derivatives of glycerol and 1,2,4-butanetriol in reactions with allyl chloride and benzyl chloride was estimated.
Role of hydroxymethyl group as a new hydrophilic 4'-pocket in 5'-norcarbocyclic nucleoside analogues
Liu, Lian Jin,Hong, Joon Hee
experimental part, p. 411 - 416 (2011/12/22)
Steric and electronic parameters of 4'-substituents play significant roles in steering the conformation of nucleoside analogues. In order to investigate the relationship of 4'-group with antiviral enhancement, novel 4'-hydroxymethyl- 5'-norcarbocyclic ade
Synthesis of diether-linked cationic lipids for gene delivery
Ren, Tan,Liu, Dexi
, p. 1247 - 1250 (2007/10/03)
Quaternary ammonium lipids 1b-d, with diether linkages between hydrocarbon chains and butane or hexane backbone, were synthesized for cationic liposome-mediated gene delivery. The synthetic strategy of using C- 4 or C-6 synthon permits the achievement of the variation of the hydrophobic domain as well as changes of space between the quaternary ammonium head and the hydrophobic domain in the diether-linked cationic lipids.
Synthesis and application of α-D-mannosyl clusters as photoaffinity ligands for mannose-binding proteins: Concanavalin A as a model receptor
Lehmann, Jochen,Weitzel, Uwe P.
, p. 65 - 94 (2007/10/03)
Mono-, di-, and tri-antennary α-D-mannopyranosyl derivatives were synthesized as oligosaccharide mimics. The compounds vary in the length of the acyclic aglyconic spacers linking, in the case of the di- and tri-antennary derivatives, the glycosyl endgroup
