171111-46-9Relevant academic research and scientific papers
Synthesis of 3-Fluoro-2-substituted amino-5,12-dihydro-5-oxobenzoxazoloquinoline-6-carboxylic Acids Employing the Tandem Double Ring Closure Reaction of N-Acetyl-N-(2-hydroxyphenyl)anthranilic Acid as the Key Step
Chung, Sang J.,Kim, Dong H.
, p. 12549 - 12562 (1995)
A general synthetic method for the preparation of 5,12-dihydro-5-oxobenzoxazoloquinoline-6-carboxylic acids has been developed making use of the tandem double ring closure reaction of N-(2-hydroxyphenyl)anthranilic acid as the key step. 2-(4-Methylpiperazin-1-yl)-3-fluoro-5,12-dihydro-5-oxobenzoxazoloquinoline-6-carboxylic acid, an oxygen isostere of a potent antibacterial, A-57,207 was thus synthesized.
