171178-44-2

Basic information

• Product Name: 6-FLUOROPYRIDO[3,4-D]PYRIMIDIN-4-OL
• Synonyms: 6-FLUOROPYRIDO[3,4-D]PYRIMIDIN-4-OL;6-Fluoropyrido[3,4-d]pyrimidin-4(1H)-one;171178-44-2;6-fluoro-1H-pyrido[3,4-d]pyrimidin-4-one
• CAS NO: 171178-44-2
• Molecular Formula: C₇H₄FN₃O
• Molecular Weight: 165.1245632
• Product Categories: Heterocycles
• Mol File: 171178-44-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 374.818 °C at 760 mmHg
• Flash Point: 180.484 °C
• Appearance: /
• Density: 1.61±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.7
• Storage Temp.: 2-8°C
• PKA: -0.92±0.20(Predicted)
• CAS DataBase Reference: 6-FLUOROPYRIDO[3,4-D]PYRIMIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUOROPYRIDO[3,4-D]PYRIMIDIN-4-OL(171178-44-2)
• EPA Substance Registry System: 6-FLUOROPYRIDO[3,4-D]PYRIMIDIN-4-OL(171178-44-2)

Safety Data

• Hazardous Substances Data: 171178-44-2(Hazardous Substances Data)

Usage

General Description

6-FLUOROPYRIDO[3,4-D]PYRIMIDIN-4-OL is a chemical compound with the molecular formula C6H4FN3O. It is a pyrimidine derivative with a fluorine atom attached to the pyridine ring. 6-FLUOROPYRIDO[3,4-D]PYRIMIDIN-4-OL is an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in organic chemistry for the production of more complex molecules. 6-FLUOROPYRIDO[3,4-D]PYRIMIDIN-4-OL is a valuable compound in medicinal and chemical research due to its unique structure and potential applications in drug discovery and development.

InChI:InChI=1/C7H4FN3O/c8-6-1-4-5(2-9-6)10-3-11-7(4)12/h1-3H,(H,10,11,12)

Upstream product

• 77287-34-4 formamide 
• 171178-43-1 5-Amino-2-fluoropyridine-4-carboxylic acid 
• 6313-33-3 formamidine hydrochloride 
• 171178-42-0 5-[N-(tert-Butoxycarbonyl)-amino]-2-fluoropyridine-4-carboxylic acid 
• 171178-41-9 (6-fluoro-pyridin-3-yl)-carbamic acid, tert-butyl ester 
• 1827-27-6 2-fluoro-5-aminopyridine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 456-24-6 2-Fluoro-5-nitropyridine 
• 3473-63-0 formamidine acetic acid 

Downstream Products

• 2135696-72-7 (E)-N-(4-((3-bromo-4-chlorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)-4-(dimethylamino)but-2-enamide 

Relevant articles and documents

USE OF QUINAZOLINE-BASED TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCERS WITH NRG1 FUSIONS

Provided herein are methods of selecting cancer patients for treatment with quinazoline-based tyrosine kinase inhibitors, either alone or in combination with anti- HER2/HER3 antibodies, as well as methods of treating cancer patients so selected. Cancer patients are selected for treatment if their cancer has an NRG1 fusion. Selected patients are then treated with quinazoline-based tyrosine kinase inhibitors alone or in combination with anti -HER2/HER3 antibodies.

A pyrido [3,4-d] pyrimidine -4 (3H)-one derivatives method for the preparation of

Belonging to the field of chemical synthesis, the invention discloses a preparation method for a pyridine[3, 4-d]pyrimidine-4(3H)-one derivative. The method includes: taking a 3-aminopyridine-4-carboxylic acid compound and an amidine compound as raw materials, adopting sodium acetate as a nucleophilic catalyst, subjecting the reaction system to reflux reaction for 4-10h in an organic solvent, and carrying out TLC detection, washing, extraction, concentration, beating and filtering so as to obtain the product pyridine[3, 4-d]pyrimidine-4(3H)-one derivative. The 3-aminopyridine-4-carboxylic acid compound, the amidine compound and sodium acetate are in a mole ratio of 1:3-5:2-4. The method provided by the invention has the advantages of easily available raw materials, mild reaction condition, well operable after-treatment, higher yield, and easy realization of large scale production.

Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

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