171178-41-9

Basic information

• Product Name: N-Boc-5-amino-2-fluoropyridine
• Synonyms: BOC-5-AMINO-2-FLUOROPYRIDINE;TERT-BUTYL 6-FLUOROPYRIDIN-3-YLCARBAMATE;Carbamic acid, (6-fluoro-3-pyridinyl)-, 1,1-dimethylethyl ester (9CI);N-Boc-5-amino-2-fluoropyridine;(6-Fluoro-pyridin-3-yl)-carbaMic acid tert-butyl ester;N-(6-fluoro-3-pyridyl)carbamic acid tert-butyl ester;tert-butyl N-(6-fluoro-3-pyridyl)carbamate;tert-butyl N-(6-fluoropyridin-3-yl)carbamate
• CAS NO: 171178-41-9
• Molecular Formula: C10H13FN2O2
• Molecular Weight: 212.22
• EINECS: 200-589-5
• Product Categories: N-BOC
• Mol File: 171178-41-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 258.294 °C at 760 mmHg
• Flash Point: 110.013 °C
• Appearance: /
• Density: 1.207 g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.529
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.91±0.70(Predicted)
• CAS DataBase Reference: N-Boc-5-amino-2-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-5-amino-2-fluoropyridine(171178-41-9)
• EPA Substance Registry System: N-Boc-5-amino-2-fluoropyridine(171178-41-9)

Safety Data

• Hazardous Substances Data: 171178-41-9(Hazardous Substances Data)

Usage

General Description

N-Boc-5-amino-2-fluoropyridine is a chemical compound with the molecular formula C12H14N2O2F. It is a derivative of pyridine and contains a fluorine atom. The "N-Boc" in its name indicates the presence of a Boc (tert-butoxycarbonyl) protecting group attached to the nitrogen atom. N-Boc-5-amino-2-fluoropyridine has potential applications in medicinal chemistry and drug discovery, as fluoropyridines are known for their biological activity and are often used as building blocks in the synthesis of pharmaceuticals. The Boc protecting group can be removed in a controlled manner to reveal the free amino group for further chemical reactions. Overall, N-Boc-5-amino-2-fluoropyridine is a versatile intermediate compound with potential applications in the pharmaceutical industry.

InChI:InChI=1/C10H13FN2O2/c1-10(2,3)15-9(14)13-7-4-5-8(11)12-6-7/h4-6H,1-3H3,(H,13,14)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1827-27-6 2-fluoro-5-aminopyridine 
• 766-11-0 5-bromo-2-fluoropyridine 
• 4248-19-5 tert-butyl carbazate 
• 4548-45-2 2-chloro-5-nitropyridine 
• 456-24-6 2-Fluoro-5-nitropyridine 

Downstream Products

• 171178-42-0 5-[N-(tert-Butoxycarbonyl)-amino]-2-fluoropyridine-4-carboxylic acid 
• 2135696-72-7 (E)-N-(4-((3-bromo-4-chlorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)-4-(dimethylamino)but-2-enamide 
• 175357-98-9 4-chloro-6-fluoro-pyrido[3,4-d]pyrimidine 
• 171178-44-2 6-fluoro-4-oxo-3H-pyrido[3,4-d]pyrimidine 
• 305371-16-8 [6-fluoro-4-(3-nitrilo-propionyl)-pyridin-3-yl]-carbamic acid, tert-butyl ester 
• 305371-15-7 5-tert-butoxycarbonylamino-2-fluoro-isonicotinic acid, methyl ester 
• 305371-17-9 6-fluoro-4-hydroxy-[1.7]naphthyridine-3-carbonitrile 
• 305371-18-0 4-chloro-6-fluoro-[1,7]naphthyridine-3-carbonitrile 
• 171178-43-1 5-Amino-2-fluoropyridine-4-carboxylic acid 

Relevant articles and documents

SUBSTITUTED 1 H-PYRROLO[3,2-B]PYRIDIN COMPOUNDS AND METHODS OF USE THEREOF

Compounds of formula (I), processes for their production and their use as pharmaceuticals.

USE OF QUINAZOLINE-BASED TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCERS WITH NRG1 FUSIONS

Provided herein are methods of selecting cancer patients for treatment with quinazoline-based tyrosine kinase inhibitors, either alone or in combination with anti- HER2/HER3 antibodies, as well as methods of treating cancer patients so selected. Cancer patients are selected for treatment if their cancer has an NRG1 fusion. Selected patients are then treated with quinazoline-based tyrosine kinase inhibitors alone or in combination with anti -HER2/HER3 antibodies.

N-Arylation of Carbamates through Photosensitized Nickel Catalysis

A highly efficient method of visible light mediated Ni(II)-catalyzed photoredox N-arylation of Cbz-amines/Boc-amines with aryl electrophiles at room temperature is reported. The methodology provides a common access to a wide variety of N-aromatic and N-heteroaromatic carbamate products that find use in the synthesis of several biologically active molecules and provides a distinct advantage over traditional palladium-catalyzed Buchwald reaction.