17152-43-1

Usage

Uses

Used in Organic Synthesis:
2-(bicyclo[2.2.1]hept-2-yl)phenol is used as a building block in organic synthesis for the creation of complex organic molecules. Its specific molecular structure allows for versatile chemical reactions, facilitating the synthesis of a range of organic compounds with potential applications in various industries.
Used in Pharmacology:
In the field of pharmacology, 2-(bicyclo[2.2.1]hept-2-yl)phenol is used as a starting material for the development of new pharmaceutical agents. Its unique chemical properties may contribute to the discovery of novel drugs with specific therapeutic effects. Further research is required to explore its potential as a pharmacological agent and to understand its mechanism of action.
Used in Chemical Research:
2-(bicyclo[2.2.1]hept-2-yl)phenol serves as a subject of study in chemical research, where its properties and reactivity are investigated. Understanding its behavior in various chemical reactions can provide insights into the development of new synthetic methods and the design of innovative molecules with specific functions.

Upstream product

• 498-66-8 norborn-2-ene 
• 108-95-2 phenol 
• 109-99-9 tetrahydrofuran 
• 139-02-6 sodium phenoxide 
• 840-90-4 2-endo-norbornyl toluenesulfonate 
• 2534-77-2 exo-2-bromonorbornane 
• 498-66-8 norbornene 

Downstream Products

• 85564-65-4 (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2R,4S)-2-bicyclo[2.2.1]hept-2-yl-phenyl ester 
• 85564-64-3 (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S,4R)-2-bicyclo[2.2.1]hept-2-yl-phenyl ester 
• 85564-73-4 2-((1R,2R,4S)-2-Bicyclo[2.2.1]hept-2-yl-phenoxymethyl)-oxirane 
• 85611-93-4 (R) 2-exo-bicyclo<2,2,1>hept-2-yl phenol 
• 85611-92-3 (S) 2-exo-bicyclo<2,2,1>hept-2-yl phenol 
• 85564-73-4 (S)-2-((1R,2R,4S)-2-Bicyclo[2.2.1]hept-2-yl-phenoxymethyl)-oxirane 
• 85564-73-4 (αR, 2R) (2-exo-bicyclo<2,2,1>hept-2-ylphenoxy) methyloxirane 
• 85564-73-4 (S)-2-((1S,2S,4R)-2-Bicyclo[2.2.1]hept-2-yl-phenoxymethyl)-oxirane 
• 85564-74-5 (αS, 2R) (2-exo-bicyclo<2,2,1>hept-2-ylphenoxy) methyloxirane 
• 85564-68-7 (αR, 2R) 3-<2-(2-exo-bicyclo<2,2,1>hept-2-yl)phenoxy>-1,2-propanediol 
• 85564-70-1 (αS, 2R) 3-<2-(2-exo-bicyclo<2,2,1>hept-2-yl)phenoxy>-1,2-propanediol 
• 85564-69-8 (S)-4-((1R,2R,4S)-2-Bicyclo[2.2.1]hept-2-yl-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 
• 85564-77-8 (S)-4-((1S,2S,4R)-2-Bicyclo[2.2.1]hept-2-yl-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 
• 85564-76-7 (αS, 2R) 1-(2-exo-bicyclo<2,2,1>hept-2-ylphenoxy)-3-<(1-methylethyl)amino>-2-propanol 

Relevant academic research and scientific papers

Addition of the ortho-C-H bonds of phenol across an olefin catalysed by a chiral iridium(I) diphosphine complex

A chiral iridium(1) diphosphine complex efficiently catalyses the unprecedented ortho-alkylation of phenol with norbornene in the absence of solvent leading to the formation of one and two C-C bonds.

Acid-Catalyzed Hydrolysis of Bridged Bi- and Tricyclic Compounds. XXVII. An Application of the Excess Acidity Method to the Norbornyl Cation Problem

Hydrolysis rates and products of exo- and endo-2-phenoxynorbornanes have been studied in concentrated aqueous perchloric acid solutions.The activation parameters, solvent deuterium isotope effects, dependences of the reation rates on acid concentration, products of hydrolysis and the high exo/endo rate ratio (2570) are all in agreement with the A-1 mechanism, in which the norbornyl cation is formed in the rate-limiting stage.The excess acidity method was used to determine first the pKa value (-5.56) and the slope parameter (m* = 1.01) for the oxygen protonation of the endo epimer, and then the slope parameters for the rate-limiting stages of the exo and endo hydrolyses (m* = 1.37 and 1.55, respectively).The slope parameters are somewhat exceptional, and may hint at a more delocalized charge in the transition state of the exo hydrolysis.

REACTION OF exo-2-NORBORNYL AND 1-ADAMANTYL p-TOLUENESULFONATES WITH SODIUM PHENOXIDE IN TETRAHYDROFORAN. IONIZATION OF THE SUBSTRATES UNDER "APPARENTLY-SN2" CONDITIONS

exo-2-Norbornyl and 1-adamantyl tosylates react with sodium phenoxide in tetrahydrofuran via ionization, most probably through a cyclic transition state.The results call for attention in interpreting substitution reactions under "apperently-SN2" conditions.