17153-21-8

Usage

Uses

Used in Pharmaceutical Industry:
3-METHYL-5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID is used as a building block for the synthesis of various pharmaceuticals due to its unique chemical structure and potential therapeutic properties. It contributes to the development of new drugs targeting a range of health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 3-METHYL-5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID is utilized as a key component in the creation of pesticides and other agrochemical products, leveraging its potential antibacterial and antifungal properties to protect crops and enhance agricultural yields.
Used in Antibacterial Applications:
3-METHYL-5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID is employed as an antibacterial agent, harnessing its ability to combat bacterial infections. It is particularly valuable in the development of new antibiotics to address the growing issue of antibiotic resistance.
Used in Antifungal Applications:
3-METHYL-5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID is also used as an antifungal agent, effective against various fungal pathogens. It is instrumental in the formulation of antifungal medications and treatments to prevent and cure fungal infections.
Used in Neurodegenerative Disease Treatment:
3-METHYL-5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID is being investigated for its potential role in treating neurodegenerative diseases. Its capacity to modulate certain biological pathways makes it a promising candidate for therapeutic intervention in conditions such as Alzheimer's and Parkinson's disease.
Used as an Enzyme Inhibitor:
Furthermore, 3-METHYL-5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID is studied for its potential as an enzyme inhibitor. Its ability to inhibit specific enzymes can be beneficial in the regulation of various biochemical processes and the treatment of enzyme-related disorders.

InChI:InChI=1/C11H9NO3/c1-7-9(11(13)14)10(15-12-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,13,14)

Upstream product

• 82140-46-3 2-benzoyl-3-methylamino-crotonic acid ethyl ester 
• 92029-29-3 ethyl 3-methyl-5-phenylisoxazole-4-carboxylate 
• 79-24-3 Nitroethane 
• 53256-23-8 ethyl β-(1-pyrrolidinyl)cinnamate 
• 93-97-0 benzoic acid anhydride 
• 1517-96-0 3-methyl-5-isoxazolone 
• 569-37-9 ethyl 3-oxo-2-benzoylbutanoate 
• 112532-09-9 4-(aminophenylmethylene)-3-methylisoxazol-5(4H)-one 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1008-75-9 3-methyl-5-phenylisoxazole 
• 91182-77-3 3-methyl-5-phenylisoxazole-4-carbonyl chloride 
• 113826-87-2 (3-methyl-5-phenylisoxazol-4-yl)methanol 

Relevant academic research and scientific papers

Design, synthesis and cytotoxic activities of scopoletin-isoxazole and scopoletin-pyrazole hybrids

12 novel scopoletin-isoxazole and scopoletin-pyrazole hybrids were designed, synthesized and their chemical structures were confirmed by HR-MS, IR,1H NMR and13C NMR spectra. The anticancer activities of the newly synthesized compounds were evaluated in vitro against three human cancer cell lines including HCT-116, Hun7 and SW620 by MTT assay. The screening results showed that six compounds (9a, 9c, 9d, 12a, 18b and 18d) exhibited potent cytotoxic activities with IC50values below 20?μM. Besides, we have further evaluated the growth inhibitory activities of six compounds against the human normal tissue cell lines HFL-1. Especially, compound 9d displayed significant anti-proliferative activity with IC50values ranging from 8.76?μM to 9.83?μM and weak cytotoxicity with IC50value of 90.9?μM on normal cells HFL-1, which suggested that isoxazole-based hybrids of scopoletin were an effective chemical modification to improve the anticancer activity of scopoletin.

Design, synthesis, and in vitro biological evaluation of 1 H -1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein

The influenza virus nucleoprotein (NP) is an emerging target for anti-influenza drug development. Nucleozin (1) and its closely related derivatives had been identified as NP inhibitors displaying anti-influenza activity. Utilizing 1 as a lead molecule, we successfully designed and synthesized a series of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents. One of the most potent compounds, 3b, inhibited the replication of various H3N2 and H1N1 influenza A virus strains with IC 50 values ranging from 0.5 to 4.6 μM. Compound 3b also strongly inhibited the replication of H5N1 (RG14), amantidine-resistant A/WSN/33 (H1N1), and oseltamivir-resistant A/WSN/1933 (H1N1, 274Y) virus strains with IC 50 values in sub-μM ranges. Further computational studies and mechanism investigation suggested that 3b might directly target influenza virus A nucleoprotein to inhibit its nuclear accumulation.