171561-54-9

Upstream product

• 98-79-3 L-Pyroglutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 
• 17342-08-4 (S)-Pyroglutaminol 
• 170885-05-9 (2R,5S)-2-(p-methoxyphenyl)-3-oxa-1-azabicyclo<3.3.0>octan-8-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 170885-07-1 (2R,5S)-2-(p-methoxyphenyl)-3-oxa-1-azabicyclo<3.3.0>oct-6-en-8-one 
• 171561-52-7 (2R,5S)-5-<2-(methoxycarbonyl)ethyl>-2-(p-methoxyphenyl)-3-oxa-1-azabicyclo<3.3.0>oct-6-en-8-one 

Relevant academic research and scientific papers

Synthesis of chiral pyrrolidine derivatives from (S)-pyroglutamic acid. II. 4-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-2-ones and 5,S-disubstituted 2-pyrrolidinones

The chiral pyrrolidine derivatives, 4-(hydroxymethyl)-3- azabicyclo[3.1.0]hexan-2-ones (10 and 11) and 5,5-disubstituted 2- pyrrolidinones (20, 21 and 22), were synthesized starting from (S)- pyroglutamic acid and absolute configuration determination was made based on the 1H-NMR spectra of the bicyclic lactam intermediates.

A New Approach to Chiral 5,5-Disubstituted 2-Pyrrolidinones from (S)-Pyroglutamic Acid

Two enentiomers of 5,5-disubstituted 2-pyrrolidinones with the certain configurations were synthesized, starting from (S)-pyroglutamic acid, via the bicyclic lactam, (2R,5S)-2-aryl-1-aza-3-oxabicyclooct-5-en-7-one (6).