171663-13-1Relevant articles and documents
COMPOUNDS AND USES THEREOF
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Page/Page column 115, (2021/08/06)
The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy
Zhang, Zhuqing,Guo, Zuhao,Xu, Xiaowei,Cao, Danyan,Yang, Hong,Li, Yanlian,Shi, Qiongyu,Du, Zhiyan,Guo, Xiaobin,Wang, Xin,Chen, Danqi,Zhang, Ying,Chen, Lin,Zhou, Kaixin,Li, Jian,Geng, Meiyu,Huang, Xun,Xiong, Bing
, p. 16650 - 16674 (2021/12/02)
CARM1 is a protein arginine methyltransferase and acts as a transcriptional coactivator regulating multiple biological processes. Aberrant expression of CARM1 has been related to the progression of multiple types of cancers, and therefore CARM1 was consid
COUMARIN-LIKE CYCLIC COMPOUND AS MEK INHIBITOR AND USE THEREOF
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Paragraph 0137-0139, (2020/05/30)
Disclosed are a class of coumarin-like cyclic compounds as MEK inhibitors and pharmaceutical compositions comprising the compounds, and the use of same in the preparation of a drug for treating MEK-related diseases. Particularly disclosed are compounds as shown in formula (I) and pharmaceutically acceptable salts thereof or tautomers thereof.